Assay Detail
Binding
CHEMBL1785674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]epibatidine from alpha4beta2* nAChR in C57BL/6J mouse cortical membrane by gamma counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha-4/beta-2 (CHEMBL3301382) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.96 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 9.30 |
| CHEMBL1783888 | — | — | 1 | 8.92 |
| CHEMBL1783886 | — | — | 1 | 8.74 |
| CHEMBL3215819 | — | — | 1 | 8.01 |
| CHEMBL1783883 | — | — | 1 | 7.96 |
| CHEMBL1783881 | — | — | 1 | 7.80 |
| CHEMBL1782074 | — | — | 1 | 7.70 |
| CHEMBL1783884 | — | — | 1 | 7.62 |
| CHEMBL1783879 | — | — | 1 | 7.60 |
| CHEMBL1783878 | — | — | 1 | 7.52 |
| CHEMBL1783882 | — | — | 1 | 7.23 |
| CHEMBL1783880 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1783888 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1783886 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL3215819 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL1783883 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1783881 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1782074 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1783884 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1783879 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1783878 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1783882 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1783880 | — | Ki | = | 69.0 | nM | 7.16 |