Assay Detail
Binding
CHEMBL1785675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL3365) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.85 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 7.16 |
| CHEMBL1783881 | — | — | 1 | 6.35 |
| CHEMBL1782074 | — | — | 1 | 6.13 |
| CHEMBL1783886 | — | — | 1 | 5.96 |
| CHEMBL3215819 | — | — | 1 | 5.68 |
| CHEMBL1783882 | — | — | 1 | 5.59 |
| CHEMBL1783883 | — | — | 1 | 5.50 |
| CHEMBL1783878 | — | — | 1 | 5.24 |
| CHEMBL1783888 | — | — | 1 | 5.04 |
| CHEMBL1783879 | — | — | 1 | - |
| CHEMBL1783880 | — | — | 1 | - |
| CHEMBL1783884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL1783881 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL1782074 | — | Ki | = | 733.0 | nM | 6.13 |
| CHEMBL1783886 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3215819 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL1783882 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL1783883 | — | Ki | = | 3160.0 | nM | 5.50 |
| CHEMBL1783878 | — | Ki | = | 5770.0 | nM | 5.24 |
| CHEMBL1783888 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL1783879 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783880 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783884 | — | Ki | > | 10000.0 | nM | - |