Assay Detail
Binding
CHEMBL1785677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at alpha4beta2*nAChR in mouse striatal synaptosomes assessed as alpha-conotoxic MII-resistant DA release
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha-4/beta-2 (CHEMBL3301382) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.58 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 7.47 |
| CHEMBL1783886 | — | — | 1 | 6.35 |
| CHEMBL1783888 | — | — | 1 | 5.75 |
| CHEMBL1783878 | — | — | 1 | 5.50 |
| CHEMBL3215819 | — | — | 1 | 5.47 |
| CHEMBL1783883 | — | — | 1 | 5.36 |
| CHEMBL1783880 | — | — | 1 | 5.23 |
| CHEMBL1783879 | — | — | 1 | 5.08 |
| CHEMBL1782074 | — | — | 1 | 4.89 |
| CHEMBL1783884 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1783886 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1783888 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1783878 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3215819 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1783883 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1783880 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1783879 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1782074 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1783884 | — | EC50 | = | 19000.0 | nM | 4.72 |