Assay Detail
Binding
CHEMBL1799273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-IBNalA from MOR-1 expressed in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Generation of novel radiolabeled opiates through site-selective iodination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.74 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 9.35 |
| CHEMBL1254682 | LEVALLORPHAN | 4.0 | 1 | 8.77 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.64 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.60 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.57 |
| CHEMBL1795717 | — | — | 1 | 8.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL1254682 | LEVALLORPHAN | Ki | = | 1.69 | nM | 8.77 |
| CHEMBL80 | NALOXONE | Ki | = | 2.27 | nM | 8.64 |
| CHEMBL70 | MORPHINE | Ki | = | 2.52 | nM | 8.60 |
| CHEMBL19019 | NALTREXONE | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL1795717 | — | Ki | = | 2.96 | nM | 8.53 |