Assay Detail
Binding
CHEMBL1804479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.67 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.47 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 1 | 6.28 |
| CHEMBL65369 | 3-HYDROXYBENZOIC ACID | — | 1 | 5.50 |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | 5.33 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 1 | 4.75 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL307145 | PYROGALLOL | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL65369 | 3-HYDROXYBENZOIC ACID | Ki | = | 3170.0 | nM | 5.50 |
| CHEMBL37537 | PROTOCATECHUIC ACID | Ki | = | 4720.0 | nM | 5.33 |
| CHEMBL506247 | TANNIC ACID | Ki | = | 17800.0 | nM | 4.75 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 2320000.0 | nM | - |