Assay Detail
Functional
CHEMBL1809342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Varicella-zoster virus OKA expressing thymidine kinase infected in human HEL cells assessed as reduction in the virus plaque formation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.34 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.52 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.85 |
| CHEMBL1807156 | — | — | 1 | 5.24 |
| CHEMBL1807159 | — | — | 1 | 5.07 |
| CHEMBL1807153 | — | — | 1 | 5.04 |
| CHEMBL1807154 | — | — | 1 | 4.96 |
| CHEMBL1807160 | — | — | 1 | 4.60 |
| CHEMBL1807161 | — | — | 1 | 4.41 |
| CHEMBL1807162 | — | — | 1 | - |
| CHEMBL1807158 | — | — | 1 | - |
| CHEMBL1807155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1807156 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1807159 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1807153 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1807154 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1807160 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1807161 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1807162 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1807158 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1807155 | — | EC50 | >= | 50000.0 | nM | - |