Assay Detail
Functional
CHEMBL1810286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Upregulation of utrophin transcription in mouse H2K cells after 48 hrs by luciferase reporter assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | H2K |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.71 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1807847 | — | — | 1 | 6.16 |
| CHEMBL1807910 | — | — | 1 | 6.12 |
| CHEMBL1807918 | — | — | 1 | 5.76 |
| CHEMBL1773683 | EZUTROMID | 2.0 | 1 | 5.75 |
| CHEMBL1806512 | — | — | 1 | 5.75 |
| CHEMBL1807843 | — | — | 1 | 5.51 |
| CHEMBL1807912 | — | — | 1 | 4.93 |
| CHEMBL1807844 | — | — | 1 | - |
| CHEMBL1807845 | — | — | 1 | - |
| CHEMBL243379 | — | — | 1 | - |
| CHEMBL1807846 | — | — | 1 | - |
| CHEMBL1413075 | — | — | 1 | - |
| CHEMBL1807914 | — | — | 1 | - |
| CHEMBL1807917 | — | — | 1 | - |
| CHEMBL1807920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1807847 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1807910 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1807918 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1773683 | EZUTROMID | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1806512 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1807843 | — | EC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL1807912 | — | EC50 | = | 11670.0 | nM | 4.93 |
| CHEMBL1807844 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1807845 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL243379 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1807846 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1413075 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1807914 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1807917 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1807920 | — | EC50 | > | 30000.0 | nM | - |