Assay Detail
ADMET
CHEMBL1816745
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Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.12 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813476 | — | — | 1 | 5.58 |
| CHEMBL1813315 | — | — | 1 | 5.28 |
| CHEMBL1813314 | — | — | 1 | 5.19 |
| CHEMBL1813471 | — | — | 1 | 5.08 |
| CHEMBL1813474 | — | — | 1 | 5.04 |
| CHEMBL1813477 | — | — | 1 | 4.97 |
| CHEMBL1813478 | — | — | 1 | 4.90 |
| CHEMBL1813472 | — | — | 1 | 4.89 |
| CHEMBL1813316 | — | — | 1 | - |
| CHEMBL1813317 | — | — | 1 | - |
| CHEMBL1813313 | — | — | 1 | - |
| CHEMBL1813470 | — | — | 1 | - |
| CHEMBL1813487 | — | — | 1 | - |
| CHEMBL1813489 | — | — | 1 | - |
| CHEMBL1813484 | — | — | 1 | - |
| CHEMBL1813475 | — | — | 1 | - |
| CHEMBL1813483 | — | — | 1 | - |
| CHEMBL1813485 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813476 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL1813315 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL1813314 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1813471 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL1813474 | — | IC50 | = | 9170.0 | nM | 5.04 |
| CHEMBL1813477 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1813478 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1813472 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1813316 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1813317 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1813313 | — | IC50 | - | — | - | |
| CHEMBL1813470 | — | IC50 | - | — | - | |
| CHEMBL1813487 | — | IC50 | - | — | - | |
| CHEMBL1813489 | — | IC50 | - | — | - | |
| CHEMBL1813484 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1813475 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1813483 | — | IC50 | - | — | - | |
| CHEMBL1813485 | — | IC50 | - | — | - |