Assay Detail
Binding
CHEMBL1909114
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DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.24 | 5.83 |
| Ki | 871 | 5.72 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | 4.0 | 2 | 6.31 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 2 | 6.28 |
| CHEMBL1221512 | — | — | 2 | 6.27 |
| CHEMBL553025 | VINORELBINE | 4.0 | 2 | 6.27 |
| CHEMBL64894 | GENTIAN VIOLET | 4.0 | 2 | 6.25 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | 6.19 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 6.19 |
| CHEMBL163 | RITONAVIR | 4.0 | 2 | 6.06 |
| CHEMBL17157 | TERFENADINE | 4.0 | 2 | 6.05 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 6.00 |
| CHEMBL1262 | OXICONAZOLE | 4.0 | 2 | 5.97 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 5.91 |
| CHEMBL787 | MONTELUKAST | 4.0 | 2 | 5.89 |
| CHEMBL81 | RALOXIFENE | 4.0 | 2 | 5.88 |
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 5.87 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 5.86 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 2 | 5.86 |
| CHEMBL153062 | 4-NONYLPHENOL | — | 2 | 5.82 |
| CHEMBL1201469 | GRAMICIDIN | 4.0 | 2 | 5.82 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 2 | 5.82 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.81 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 5.79 |
| CHEMBL1221 | SULCONAZOLE | 4.0 | 2 | 5.78 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 2 | 5.77 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 2 | 5.71 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 5.70 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 5.69 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 2 | 5.68 |
| CHEMBL404849 | SULOCTIDIL | 4.0 | 2 | 5.64 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | Ki | = | 491.0 | nM | 6.31 |
| CHEMBL3545252 | DOCETAXEL | Ki | = | 521.0 | nM | 6.28 |
| CHEMBL553025 | VINORELBINE | Ki | = | 535.55 | nM | 6.27 |
| CHEMBL1221512 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL64894 | GENTIAN VIOLET | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL305660 | EBASTINE | Ki | = | 644.3 | nM | 6.19 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL163 | RITONAVIR | Ki | = | 874.0 | nM | 6.06 |
| CHEMBL17157 | TERFENADINE | Ki | = | 892.0 | nM | 6.05 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 995.0 | nM | 6.00 |
| CHEMBL1262 | OXICONAZOLE | Ki | = | 1073.9 | nM | 5.97 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 1223.0 | nM | 5.91 |
| CHEMBL787 | MONTELUKAST | Ki | = | 1274.0 | nM | 5.89 |
| CHEMBL81 | RALOXIFENE | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL19215 | METERGOLINE | Ki | = | 1357.0 | nM | 5.87 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL496 | HEXACHLOROPHENE | Ki | = | 1379.7 | nM | 5.86 |
| CHEMBL1289 | HALOPROGIN | IC50 | = | 1474.0 | nM | 5.83 |
| CHEMBL954 | ENCLOMIPHENE | Ki | = | 1508.0 | nM | 5.82 |
| CHEMBL1201469 | GRAMICIDIN | Ki | = | 1521.0 | nM | 5.82 |
| CHEMBL153062 | 4-NONYLPHENOL | Ki | = | 1505.0 | nM | 5.82 |
| CHEMBL290106 | BITHIONOL | Ki | = | 1553.0 | nM | 5.81 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1563.0 | nM | 5.81 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1606.2 | nM | 5.79 |
| CHEMBL1221512 | — | IC50 | = | 1609.0 | nM | 5.79 |
| CHEMBL91 | MICONAZOLE | Ki | = | 1613.0 | nM | 5.79 |
| CHEMBL1221 | SULCONAZOLE | Ki | = | 1653.0 | nM | 5.78 |
| CHEMBL64894 | GENTIAN VIOLET | IC50 | = | 1679.0 | nM | 5.78 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 1925.0 | nM | 5.72 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | Ki | = | 1949.0 | nM | 5.71 |
| CHEMBL305660 | EBASTINE | IC50 | = | 1932.9 | nM | 5.71 |
| CHEMBL808 | ECONAZOLE | Ki | = | 2011.0 | nM | 5.70 |
| CHEMBL428647 | PACLITAXEL | Ki | = | 2042.0 | nM | 5.69 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 2071.0 | nM | 5.68 |
| CHEMBL404849 | SULOCTIDIL | Ki | = | 2264.3 | nM | 5.64 |
| CHEMBL163 | RITONAVIR | IC50 | = | 2622.0 | nM | 5.58 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 2677.0 | nM | 5.57 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | Ki | = | 2877.0 | nM | 5.54 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 2986.0 | nM | 5.53 |
| CHEMBL411 | DIETHYLSTILBESTROL | Ki | = | 3184.0 | nM | 5.50 |
| CHEMBL1262 | OXICONAZOLE | IC50 | = | 3221.8 | nM | 5.49 |
| CHEMBL104 | CLOTRIMAZOLE | Ki | = | 3383.0 | nM | 5.47 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 3822.0 | nM | 5.42 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 3989.0 | nM | 5.40 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 4071.0 | nM | 5.39 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 4139.0 | nM | 5.38 |
| CHEMBL7002 | CIGLITAZONE | Ki | = | 4192.0 | nM | 5.38 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 4139.2 | nM | 5.38 |