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Assay Detail

CHEMBL1909199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 3 (CHEMBL3385) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.35 6.11
Ki 871 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL508338 THIMEROSAL 3.0 2 6.11
CHEMBL964 DISULFIRAM 4.0 2 5.82
CHEMBL496 HEXACHLOROPHENE 4.0 2 5.61
CHEMBL1062 HYDROXYPROGESTERONE — 2 5.50
CHEMBL506247 TANNIC ACID 4.0 2 5.39
CHEMBL603 ZAFIRLUKAST 4.0 2 5.36
CHEMBL11359 CISPLATIN 4.0 2 5.33
CHEMBL141343 — — 2 5.30
CHEMBL86754 IODOQUINOL 2.0 2 5.28
CHEMBL26260 BETA-NAPHTHOFLAVONE — 2 5.26
CHEMBL727 THIOGUANINE 4.0 2 5.26
CHEMBL460499 CARMOFUR 2.0 2 5.21
CHEMBL1630578 TIRILAZAD 3.0 2 4.79
CHEMBL584 NELFINAVIR 4.0 2 4.65
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL388590 BENZBROMARONE 4.0 2 -
CHEMBL1200558 BACITRACIN 4.0 2 -
CHEMBL515914 AZARIBINE 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL508338 THIMEROSAL IC50 = 774.0 nM 6.11
CHEMBL964 DISULFIRAM IC50 = 1510.0 nM 5.82
CHEMBL496 HEXACHLOROPHENE IC50 = 2484.4 nM 5.61
CHEMBL1062 HYDROXYPROGESTERONE IC50 = 3157.0 nM 5.50
CHEMBL506247 TANNIC ACID IC50 = 4052.0 nM 5.39
CHEMBL603 ZAFIRLUKAST IC50 = 4376.0 nM 5.36
CHEMBL11359 CISPLATIN IC50 = 4624.0 nM 5.33
CHEMBL141343 — IC50 = 4962.0 nM 5.30
CHEMBL86754 IODOQUINOL IC50 = 5264.0 nM 5.28
CHEMBL26260 BETA-NAPHTHOFLAVONE IC50 = 5466.7 nM 5.26
CHEMBL727 THIOGUANINE IC50 = 5516.0 nM 5.26
CHEMBL460499 CARMOFUR IC50 = 6121.0 nM 5.21
CHEMBL1630578 TIRILAZAD IC50 = 16262.0 nM 4.79
CHEMBL584 NELFINAVIR IC50 = 22503.0 nM 4.65
CHEMBL1201237 LEVOBUNOLOL Ki - — -
CHEMBL19019 NALTREXONE IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 Ki - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE IC50 - — -
CHEMBL1373 MODAFINIL Ki - — -
CHEMBL1373 MODAFINIL IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL503 LOVASTATIN IC50 - — -
CHEMBL64391 ITRACONAZOLE Ki - — -
CHEMBL64391 ITRACONAZOLE IC50 - — -
CHEMBL92401 IPRONIAZID Ki - — -
CHEMBL92401 IPRONIAZID IC50 - — -
CHEMBL1201151 MESTRANOL Ki - — -
CHEMBL21731 MAPROTILINE Ki - — -
CHEMBL1201151 MESTRANOL IC50 - — -
CHEMBL547 ISOTRETINOIN IC50 - — -
CHEMBL547 ISOTRETINOIN Ki - — -
CHEMBL534 KETOTIFEN IC50 - — -
CHEMBL534 KETOTIFEN Ki - — -
CHEMBL191 LOSARTAN IC50 - — -
CHEMBL191 LOSARTAN Ki - — -
CHEMBL21731 MAPROTILINE IC50 - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL86304 MOCLOBEMIDE Ki - — -
CHEMBL1630579 MYRTECAINE IC50 - — -
CHEMBL1630579 MYRTECAINE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL741 LAMOTRIGINE IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -