Assay Detail
Binding
CHEMBL1929758
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Displacement of [3H]testosterone from AR
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.89 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928877 | — | — | 1 | 7.02 |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 6.92 |
| CHEMBL1928878 | — | — | 1 | 5.92 |
| CHEMBL1928872 | — | — | 1 | 5.44 |
| CHEMBL1929041 | — | — | 1 | 5.35 |
| CHEMBL1928875 | — | — | 1 | 5.33 |
| CHEMBL1928874 | — | — | 1 | 5.23 |
| CHEMBL1928870 | — | — | 1 | - |
| CHEMBL1928871 | — | — | 1 | - |
| CHEMBL1928873 | — | — | 1 | - |
| CHEMBL1928876 | — | — | 1 | - |
| CHEMBL1928869 | — | — | 1 | - |
| CHEMBL1928880 | — | — | 1 | - |
| CHEMBL1928881 | — | — | 1 | - |
| CHEMBL1928882 | — | — | 1 | - |
| CHEMBL1929036 | — | — | 1 | - |
| CHEMBL1929039 | — | — | 1 | - |
| CHEMBL1929040 | — | — | 1 | - |
| CHEMBL1929042 | — | — | 1 | - |
| CHEMBL1095097 | EPLERENONE | 4.0 | 1 | - |
| CHEMBL1928879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928877 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1393 | SPIRONOLACTONE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1928878 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1928872 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1929041 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1928875 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1928874 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1928870 | — | IC50 | - | — | - | |
| CHEMBL1928871 | — | IC50 | - | — | - | |
| CHEMBL1928873 | — | IC50 | - | — | - | |
| CHEMBL1928876 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1928869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1928880 | — | IC50 | - | — | - | |
| CHEMBL1928881 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1928882 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1929036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1929039 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1929040 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1929042 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095097 | EPLERENONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1928879 | — | IC50 | - | — | - |