Assay Detail
Binding
CHEMBL1937030
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Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells
12
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cell-based and in-silico studies on the high intrinsic activity of two boron-containing salbutamol derivatives at the human β₂-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.54 | 6.30 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1711 | ISOPROTERENOL HYDROCHLORIDE | 4.0 | 3 | 6.30 |
| CHEMBL2068576 | — | — | 3 | 5.41 |
| CHEMBL1002 | LEVOSALBUTAMOL | 4.0 | 3 | 5.25 |
| CHEMBL2068577 | — | — | 3 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1711 | ISOPROTERENOL HYDROCHLORIDE | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL1711 | ISOPROTERENOL HYDROCHLORIDE | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL2068576 | — | Ki | = | 3890.0 | nM | 5.41 |
| CHEMBL2068576 | — | Ki | = | 3890.45 | nM | 5.41 |
| CHEMBL1002 | LEVOSALBUTAMOL | Ki | = | 5623.0 | nM | 5.25 |
| CHEMBL1002 | LEVOSALBUTAMOL | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL2068577 | — | Ki | = | 6607.0 | nM | 5.18 |
| CHEMBL2068577 | — | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL1711 | ISOPROTERENOL HYDROCHLORIDE | Inhibition | - | % | - | |
| CHEMBL2068577 | — | Inhibition | - | % | - | |
| CHEMBL2068576 | — | Inhibition | - | % | - | |
| CHEMBL1002 | LEVOSALBUTAMOL | Inhibition | - | % | - |