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Compound Detail

CHEMBL1002

LEVOSALBUTAMOL
💊 Approved Drug
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💊 Approved Drug
CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1002
Name LEVOSALBUTAMOL
Phase Approved
Structure Type MOL
InChI Key NDAUXUAQIAJITI-LBPRGKRZSA-N
Therapeutic ✓ Yes

Known Names

Albuterol (r)-form ASF-1096 Levalbuterol Levosalbutamol R-salbutamol
1
Targets
12
Activities
2
Assay Types
0
PK Parameters
7
Publications
5
Known Names
2
Indications

Molecular Properties

239.3
MW (Da)
1.31
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1999
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Topical

Flags

Black Box Warning Natural Product
USAN Stem -sal-
USAN Year 1997

Extended Properties

Molecular Formula C13H21NO3
MW 239.31
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness 0.56

Indications

Asthma Pulmonary Disease, Chronic Obstructive

Activity Summary

EC50 6 meas. best 6.84
Ki 6 meas. best 5.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
 EC50 6.84 6.58 144.5 6
Beta-2 adrenergic receptor
CHEMBL210
 Ki 5.42 5.3333 3801.9 6

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Beta-2 adrenergic receptor EC50 = 145.0 nM 6.84 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor EC50 = 144.54 nM 6.84 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor EC50 = 275.0 nM 6.56 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor EC50 = 275.42 nM 6.56 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor EC50 = 457.0 nM 6.34 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor EC50 = 457.09 nM 6.34 Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T ce... 22182578
Beta-2 adrenergic receptor Ki = 3802.0 nM 5.42 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578
Beta-2 adrenergic receptor Ki = 3801.89 nM 5.42 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578
Beta-2 adrenergic receptor Ki = 4677.0 nM 5.33 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578
Beta-2 adrenergic receptor Ki = 4677.35 nM 5.33 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578
Beta-2 adrenergic receptor Ki = 5623.0 nM 5.25 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578
Beta-2 adrenergic receptor Ki = 5623.41 nM 5.25 Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in ... 22182578

Literature References

PubMed DOI Target Context # Activities
22182578 10.1016/j.bmc.2011.11.054 Beta-2 adrenergic receptor 19
22182578 10.1016/j.bmc.2011.11.054 Unchecked 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
3005570 10.1021/jm00152a017 Erythrocyte beta receptor 1
10841799 10.1021/jm990968+ Mus musculus 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
38318365 10.1016/j.isci.2024.108907 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1

Data from ChEMBL 36 via Core Engine