Assay Detail
Functional
CHEMBL1948905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against P2/AT1 double knockout Trypanosoma brucei after 3 days by resazurin-based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinol derivatives as potential trypanocidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.24 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1944644 | — | — | 1 | 7.13 |
| CHEMBL222088 | — | — | 1 | 7.10 |
| CHEMBL1944646 | — | — | 1 | 6.58 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 6.48 |
| CHEMBL1945425 | — | — | 1 | 5.75 |
| CHEMBL1945424 | — | — | 1 | 5.42 |
| CHEMBL1945423 | — | — | 1 | 5.22 |
| CHEMBL223812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1944644 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL222088 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1944646 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1945425 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1945424 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1945423 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL223812 | — | EC50 | - | — | - |