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Assay Detail

CHEMBL1963712

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SYK
ChEMBL ↗
531
Total Activities
525
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase SYK (CHEMBL2599) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 531 6.53 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1987034 — — 1 8.50
CHEMBL1980995 — — 1 8.50
CHEMBL475251 R-406 2.0 1 8.20
CHEMBL379975 — — 1 8.20
CHEMBL1984162 — — 1 8.00
CHEMBL244378 — — 1 8.00
CHEMBL1997924 — — 1 7.90
CHEMBL1998112 — — 1 7.90
CHEMBL1970104 — — 2 7.80
CHEMBL2005886 — — 1 7.80
CHEMBL1996048 — — 1 7.80
CHEMBL1994669 — — 1 7.70
CHEMBL1991078 — — 1 7.70
CHEMBL1976134 — — 1 7.50
CHEMBL396523 — — 1 7.50
CHEMBL1983111 — — 1 7.50
CHEMBL1988163 — — 1 7.40
CHEMBL1984548 — — 1 7.30
CHEMBL1989708 — — 2 7.30
CHEMBL1980297 ILORASERTIB 2.0 1 7.30
CHEMBL1993424 — — 1 7.20
CHEMBL1725279 SP-600125 — 1 7.20
CHEMBL1967720 — — 1 7.20
CHEMBL243088 — — 1 7.20
CHEMBL1982957 — — 1 7.10
CHEMBL49120 PD-0166285 1.0 1 7.10
CHEMBL509032 TAE-684 — 1 7.10
CHEMBL1986263 — — 1 7.10
CHEMBL2002165 — — 1 7.10
CHEMBL592030 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1987034 — Ki = 3.162 nM 8.50
CHEMBL1980995 — Ki = 3.162 nM 8.50
CHEMBL475251 R-406 Ki = 6.31 nM 8.20
CHEMBL379975 — Ki = 6.31 nM 8.20
CHEMBL1984162 — Ki = 10.0 nM 8.00
CHEMBL244378 — Ki = 10.0 nM 8.00
CHEMBL1998112 — Ki = 12.59 nM 7.90
CHEMBL1997924 — Ki = 12.59 nM 7.90
CHEMBL2005886 — Ki = 15.85 nM 7.80
CHEMBL1970104 — Ki = 15.85 nM 7.80
CHEMBL1996048 — Ki = 15.85 nM 7.80
CHEMBL1970104 — Ki = 15.85 nM 7.80
CHEMBL1991078 — Ki = 19.95 nM 7.70
CHEMBL1994669 — Ki = 19.95 nM 7.70
CHEMBL396523 — Ki = 31.62 nM 7.50
CHEMBL1983111 — Ki = 31.62 nM 7.50
CHEMBL1976134 — Ki = 31.62 nM 7.50
CHEMBL1988163 — Ki = 39.81 nM 7.40
CHEMBL1980297 ILORASERTIB Ki = 50.12 nM 7.30
CHEMBL1984548 — Ki = 50.12 nM 7.30
CHEMBL1989708 — Ki = 50.12 nM 7.30
CHEMBL1989708 — Ki = 50.12 nM 7.30
CHEMBL243088 — Ki = 63.1 nM 7.20
CHEMBL1725279 SP-600125 Ki = 63.1 nM 7.20
CHEMBL1967720 — Ki = 63.1 nM 7.20
CHEMBL1993424 — Ki = 63.1 nM 7.20
CHEMBL49120 PD-0166285 Ki = 79.43 nM 7.10
CHEMBL509032 TAE-684 Ki = 79.43 nM 7.10
CHEMBL1982957 — Ki = 79.43 nM 7.10
CHEMBL1986263 — Ki = 79.43 nM 7.10
CHEMBL2002165 — Ki = 79.43 nM 7.10
CHEMBL592030 — Ki = 100.0 nM 7.00
CHEMBL1974664 — Ki = 100.0 nM 7.00
CHEMBL1993941 — Ki = 125.89 nM 6.90
CHEMBL1999931 — Ki = 125.89 nM 6.90
CHEMBL1969502 — Ki = 158.49 nM 6.80
CHEMBL1980391 RG-1530 Ki = 158.49 nM 6.80
CHEMBL5416410 DASATINIB Ki = 199.53 nM 6.70
CHEMBL2000832 — Ki = 199.53 nM 6.70
CHEMBL1974254 — Ki = 199.53 nM 6.70
CHEMBL1976040 ADAVOSERTIB Ki = 199.53 nM 6.70
CHEMBL1985095 — Ki = 199.53 nM 6.70
CHEMBL1998585 — Ki = 251.19 nM 6.60
CHEMBL491758 — Ki = 251.19 nM 6.60
CHEMBL583144 — Ki = 316.23 nM 6.50
CHEMBL1975500 — Ki = 316.23 nM 6.50
CHEMBL1978448 — Ki = 316.23 nM 6.50
CHEMBL1988838 — Ki = 316.23 nM 6.50
CHEMBL1968406 — Ki = 316.23 nM 6.50
CHEMBL1983923 — Ki = 316.23 nM 6.50