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Assay Detail

CHEMBL1963798

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCI
ChEMBL ↗
483
Total Activities
474
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein kinase C iota type (CHEMBL2598) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 483 5.88 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL592030 — — 1 8.50
CHEMBL1966628 — — 1 7.50
CHEMBL220241 GSK-269962A — 1 7.50
CHEMBL1985095 — — 1 7.20
CHEMBL1995813 — — 1 6.70
CHEMBL1998159 — — 1 6.60
CHEMBL1991674 — — 1 6.40
CHEMBL565612 SOTRASTAURIN 2.0 1 6.40
CHEMBL1998121 — — 1 6.30
CHEMBL1965660 — — 2 6.10
CHEMBL1997846 — — 1 6.00
CHEMBL1975138 — — 1 6.00
CHEMBL1991063 — — 1 6.00
CHEMBL1974870 — — 1 6.00
CHEMBL1990635 — — 1 6.00
CHEMBL1990496 — — 1 6.00
CHEMBL1967878 CENISERTIB 2.0 1 5.90
CHEMBL1975128 — — 1 5.80
CHEMBL1966425 — — 1 5.80
CHEMBL1999931 — — 1 5.80
CHEMBL1968705 — — 1 5.80
CHEMBL2004716 — — 1 5.70
CHEMBL1993661 — — 1 5.70
CHEMBL1988173 — — 1 5.60
CHEMBL1986943 — — 2 5.60
CHEMBL1982711 — — 1 5.60
CHEMBL1981725 — — 1 5.60
CHEMBL1972584 — — 2 5.60
CHEMBL1973211 — — 1 5.60
CHEMBL1972158 — — 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL592030 — Ki = 3.162 nM 8.50
CHEMBL1966628 — Ki = 31.62 nM 7.50
CHEMBL220241 GSK-269962A Ki = 31.62 nM 7.50
CHEMBL1985095 — Ki = 63.1 nM 7.20
CHEMBL1995813 — Ki = 199.53 nM 6.70
CHEMBL1998159 — Ki = 251.19 nM 6.60
CHEMBL565612 SOTRASTAURIN Ki = 398.11 nM 6.40
CHEMBL1991674 — Ki = 398.11 nM 6.40
CHEMBL1998121 — Ki = 501.19 nM 6.30
CHEMBL1965660 — Ki = 794.33 nM 6.10
CHEMBL1965660 — Ki = 794.33 nM 6.10
CHEMBL1990635 — Ki = 1000.0 nM 6.00
CHEMBL1990496 — Ki = 1000.0 nM 6.00
CHEMBL1975138 — Ki = 1000.0 nM 6.00
CHEMBL1991063 — Ki = 1000.0 nM 6.00
CHEMBL1997846 — Ki = 1000.0 nM 6.00
CHEMBL1974870 — Ki = 1000.0 nM 6.00
CHEMBL1967878 CENISERTIB Ki = 1258.93 nM 5.90
CHEMBL1968705 — Ki = 1584.89 nM 5.80
CHEMBL1966425 — Ki = 1584.89 nM 5.80
CHEMBL1975128 — Ki = 1584.89 nM 5.80
CHEMBL1999931 — Ki = 1584.89 nM 5.80
CHEMBL2004716 — Ki = 1995.26 nM 5.70
CHEMBL1993661 — Ki = 1995.26 nM 5.70
CHEMBL1972584 — Ki = 2511.89 nM 5.60
CHEMBL1988173 — Ki = 2511.89 nM 5.60
CHEMBL1987910 — Ki = 2511.89 nM 5.60
CHEMBL1965836 — Ki = 2511.89 nM 5.60
CHEMBL2000481 — Ki = 2511.89 nM 5.60
CHEMBL1986943 — Ki = 2511.89 nM 5.60
CHEMBL1981725 — Ki = 2511.89 nM 5.60
CHEMBL1979883 — Ki = 2511.89 nM 5.60
CHEMBL1986943 — Ki = 2511.89 nM 5.60
CHEMBL1973211 — Ki = 2511.89 nM 5.60
CHEMBL1982711 — Ki = 2511.89 nM 5.60
CHEMBL1972584 — Ki = 2511.89 nM 5.60
CHEMBL340384 — Ki = 2511.89 nM 5.60
CHEMBL1972158 — Ki = 2511.89 nM 5.60
CHEMBL1974328 — Ki = 3162.28 nM 5.50
CHEMBL1980297 ILORASERTIB Ki = 3162.28 nM 5.50
CHEMBL1975490 — Ki = 3162.28 nM 5.50
CHEMBL1993548 — Ki = 3162.28 nM 5.50
CHEMBL1987982 — Ki = 3162.28 nM 5.50
CHEMBL1982361 — Ki = 3162.28 nM 5.50
CHEMBL1967531 — Ki = 3162.28 nM 5.50
CHEMBL2002479 — Ki = 3981.07 nM 5.40
CHEMBL1968791 — Ki = 3981.07 nM 5.40
CHEMBL2002992 — Ki = 3981.07 nM 5.40
CHEMBL1967720 — Ki = 3981.07 nM 5.40
CHEMBL1991078 — Ki = 3981.07 nM 5.40