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Assay Detail

CHEMBL1964103

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MST1R
ChEMBL ↗
325
Total Activities
316
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Macrophage-stimulating protein receptor (CHEMBL2689) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 325 5.96 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.60
CHEMBL1980407 — — 1 8.80
CHEMBL1967878 CENISERTIB 2.0 1 8.40
CHEMBL1993661 — — 1 8.10
CHEMBL1980297 ILORASERTIB 2.0 1 8.00
CHEMBL1983111 — — 1 7.70
CHEMBL1990885 — — 1 7.60
CHEMBL2006564 — — 1 7.60
CHEMBL522892 DOVITINIB 3.0 1 7.60
CHEMBL21156 — — 1 7.50
CHEMBL1989708 — — 1 7.50
CHEMBL1972220 — — 1 7.50
CHEMBL1980391 RG-1530 1.0 1 7.40
CHEMBL1981047 — — 1 7.20
CHEMBL1973720 — — 2 7.20
CHEMBL1980329 — — 1 7.20
CHEMBL1969151 — — 1 7.10
CHEMBL1986943 — — 2 7.00
CHEMBL1996510 — — 1 7.00
CHEMBL1164180 — — 1 7.00
CHEMBL191003 JNJ-7706621 — 1 7.00
CHEMBL1988581 — — 1 7.00
CHEMBL2006765 — — 1 7.00
CHEMBL509032 TAE-684 — 1 6.90
CHEMBL1081312 — — 1 6.90
CHEMBL1996176 — — 2 6.90
CHEMBL1977138 — — 1 6.80
CHEMBL379975 — — 1 6.80
CHEMBL565612 SOTRASTAURIN 2.0 1 6.80
CHEMBL1974328 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.2512 nM 9.60
CHEMBL1980407 — Ki = 1.585 nM 8.80
CHEMBL1967878 CENISERTIB Ki = 3.981 nM 8.40
CHEMBL1993661 — Ki = 7.943 nM 8.10
CHEMBL1980297 ILORASERTIB Ki = 10.0 nM 8.00
CHEMBL1983111 — Ki = 19.95 nM 7.70
CHEMBL1990885 — Ki = 25.12 nM 7.60
CHEMBL522892 DOVITINIB Ki = 25.12 nM 7.60
CHEMBL2006564 — Ki = 25.12 nM 7.60
CHEMBL1989708 — Ki = 31.62 nM 7.50
CHEMBL1972220 — Ki = 31.62 nM 7.50
CHEMBL21156 — Ki = 31.62 nM 7.50
CHEMBL1980391 RG-1530 Ki = 39.81 nM 7.40
CHEMBL1973720 — Ki = 63.1 nM 7.20
CHEMBL1981047 — Ki = 63.1 nM 7.20
CHEMBL1980329 — Ki = 63.1 nM 7.20
CHEMBL1973720 — Ki = 63.1 nM 7.20
CHEMBL1969151 — Ki = 79.43 nM 7.10
CHEMBL1986943 — Ki = 100.0 nM 7.00
CHEMBL1996510 — Ki = 100.0 nM 7.00
CHEMBL1164180 — Ki = 100.0 nM 7.00
CHEMBL191003 JNJ-7706621 Ki = 100.0 nM 7.00
CHEMBL2006765 — Ki = 100.0 nM 7.00
CHEMBL1986943 — Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 100.0 nM 7.00
CHEMBL509032 TAE-684 Ki = 125.89 nM 6.90
CHEMBL1081312 — Ki = 125.89 nM 6.90
CHEMBL1996176 — Ki = 125.89 nM 6.90
CHEMBL565612 SOTRASTAURIN Ki = 158.49 nM 6.80
CHEMBL1977138 — Ki = 158.49 nM 6.80
CHEMBL379975 — Ki = 158.49 nM 6.80
CHEMBL1996176 — Ki = 199.53 nM 6.70
CHEMBL1970317 — Ki = 199.53 nM 6.70
CHEMBL1983575 — Ki = 199.53 nM 6.70
CHEMBL2007421 — Ki = 199.53 nM 6.70
CHEMBL1974328 — Ki = 199.53 nM 6.70
CHEMBL360847 — Ki = 199.53 nM 6.70
CHEMBL1084546 PF-00562271 Ki = 251.19 nM 6.60
CHEMBL1965170 — Ki = 251.19 nM 6.60
CHEMBL1983268 ENTRECTINIB Ki = 251.19 nM 6.60
CHEMBL1996649 — Ki = 251.19 nM 6.60
CHEMBL1988437 — Ki = 251.19 nM 6.60
CHEMBL2004290 — Ki = 316.23 nM 6.50
CHEMBL1996048 — Ki = 316.23 nM 6.50
CHEMBL1999414 — Ki = 316.23 nM 6.50
CHEMBL1825138 — Ki = 316.23 nM 6.50
CHEMBL1995211 — Ki = 316.23 nM 6.50
CHEMBL1985681 — Ki = 316.23 nM 6.50
CHEMBL1973516 — Ki = 316.23 nM 6.50
CHEMBL1983923 — Ki = 398.11 nM 6.40