Assay Detail
Functional
CHEMBL1964118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FRK
496
Total Activities
485
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | other |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 496 | 6.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1993661 | — | — | 1 | 9.00 |
| CHEMBL1984162 | — | — | 1 | 9.00 |
| CHEMBL1981047 | — | — | 1 | 8.90 |
| CHEMBL1992306 | — | — | 1 | 8.70 |
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.70 |
| CHEMBL509032 | TAE-684 | — | 1 | 8.60 |
| CHEMBL1988387 | — | — | 1 | 8.60 |
| CHEMBL1964692 | — | — | 1 | 8.60 |
| CHEMBL1970142 | — | — | 1 | 8.50 |
| CHEMBL1996979 | — | — | 1 | 8.50 |
| CHEMBL306380 | — | — | 1 | 8.50 |
| CHEMBL1994938 | — | — | 1 | 8.50 |
| CHEMBL1989708 | — | — | 2 | 8.40 |
| CHEMBL259922 | — | — | 1 | 8.40 |
| CHEMBL2004716 | — | — | 1 | 8.30 |
| CHEMBL1982466 | — | — | 1 | 8.30 |
| CHEMBL1998585 | — | — | 1 | 8.30 |
| CHEMBL1988717 | — | — | 1 | 8.20 |
| CHEMBL1090356 | — | — | 1 | 8.20 |
| CHEMBL213505 | — | — | 1 | 8.10 |
| CHEMBL1974328 | — | — | 1 | 8.00 |
| CHEMBL1993424 | — | — | 1 | 8.00 |
| CHEMBL2005886 | — | — | 1 | 7.90 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.90 |
| CHEMBL1987034 | — | — | 1 | 7.80 |
| CHEMBL1977148 | — | — | 1 | 7.80 |
| CHEMBL2001485 | — | — | 1 | 7.80 |
| CHEMBL1993243 | — | — | 1 | 7.80 |
| CHEMBL508928 | — | — | 1 | 7.80 |
| CHEMBL1983268 | ENTRECTINIB | 4.0 | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1984162 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1993661 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1981047 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL1992306 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL1980297 | ILORASERTIB | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL509032 | TAE-684 | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1988387 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1964692 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL306380 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1996979 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1994938 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1970142 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1989708 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL259922 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1998585 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL1982466 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2004716 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL1988717 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1989708 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1090356 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL213505 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1974328 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1993424 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL475251 | R-406 | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL2005886 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1977148 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1983268 | ENTRECTINIB | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL2001485 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1987034 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL508928 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1993243 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL271381 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL262433 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2004311 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL458997 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL223360 | LINIFANIB | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2006715 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1968406 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL371206 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1968791 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL253969 | OSI-632 | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL2002649 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL2002165 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1993941 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL2001257 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1973540 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1682553 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1972584 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL220057 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1971021 | — | Ki | = | 31.62 | nM | 7.50 |