Assay Detail
Binding
CHEMBL2019953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation counting
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.89 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372700 | FENPROPIMORPH | — | 1 | 10.96 |
| CHEMBL473783 | — | — | 1 | 10.01 |
| CHEMBL2017957 | — | — | 1 | 8.73 |
| CHEMBL559292 | — | — | 1 | 8.59 |
| CHEMBL472979 | — | — | 1 | 8.45 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.24 |
| CHEMBL551856 | — | — | 1 | 8.15 |
| CHEMBL559979 | — | — | 1 | 7.89 |
| CHEMBL560 | — | — | 1 | 7.82 |
| CHEMBL557297 | — | — | 1 | 7.65 |
| CHEMBL2017958 | — | — | 1 | 7.52 |
| CHEMBL564522 | — | — | 1 | 6.65 |
| CHEMBL474182 | — | — | 1 | 5.99 |
| CHEMBL562450 | — | — | 1 | 5.94 |
| CHEMBL2017959 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372700 | FENPROPIMORPH | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL473783 | — | Ki | = | 0.098 | nM | 10.01 |
| CHEMBL2017957 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL559292 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL472979 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL551856 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL559979 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL560 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL557297 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL2017958 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL564522 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL474182 | — | Ki | = | 1017.0 | nM | 5.99 |
| CHEMBL562450 | — | Ki | = | 1147.0 | nM | 5.94 |
| CHEMBL2017959 | — | Ki | = | 1578.0 | nM | 5.80 |