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Assay Detail

CHEMBL2032598

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human cisplatin sensitive A2780 cells after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Autocuration

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides.
Wollinsky B, Ludwig L, Hamacher A, Yu X, Kassack MU, Li SM.
Bioorg Med Chem Lett (2012) 22 : 3866 -3869
PubMed 22617493 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 4.05 4.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2031711 1 4.11
CHEMBL2031705 1 4.08
CHEMBL36668 TRYPROSTATIN B 1 4.08
CHEMBL2031712 1 4.07
CHEMBL2031713 1 4.06
CHEMBL2031709 1 4.06
CHEMBL2031710 1 4.05
CHEMBL2031708 1 4.05
CHEMBL2031707 1 4.05
CHEMBL2031714 1 4.04
CHEMBL2031706 1 4.03
CHEMBL288188 1 4.03
CHEMBL35821 1 4.00
CHEMBL2031513 1 -
CHEMBL2031514 1 -
CHEMBL2031704 1 -
CHEMBL2031511 1 -
CHEMBL2031510 1 -
CHEMBL2031509 1 -
CHEMBL2031508 1 -
CHEMBL2031512 1 -
CHEMBL38396 1 -
CHEMBL191476 1 -
CHEMBL191011 1 -
CHEMBL365348 1 -
CHEMBL226544 1 -
CHEMBL563557 BREVIANAMIDE F 1 -
CHEMBL190059 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2031711 IC50 = 77200.0 nM 4.11
CHEMBL2031705 IC50 = 82400.0 nM 4.08
CHEMBL36668 TRYPROSTATIN B IC50 = 82800.0 nM 4.08
CHEMBL2031712 IC50 = 85000.0 nM 4.07
CHEMBL2031713 IC50 = 86200.0 nM 4.06
CHEMBL2031709 IC50 = 87000.0 nM 4.06
CHEMBL2031710 IC50 = 89800.0 nM 4.05
CHEMBL2031708 IC50 = 89800.0 nM 4.05
CHEMBL2031707 IC50 = 89700.0 nM 4.05
CHEMBL2031714 IC50 = 91800.0 nM 4.04
CHEMBL2031706 IC50 = 92600.0 nM 4.03
CHEMBL288188 IC50 = 93100.0 nM 4.03
CHEMBL35821 IC50 = 100000.0 nM 4.00
CHEMBL2031513 IC50 > 100000.0 nM -
CHEMBL2031514 IC50 > 100000.0 nM -
CHEMBL2031704 IC50 > 100000.0 nM -
CHEMBL2031511 IC50 > 100000.0 nM -
CHEMBL2031510 IC50 > 100000.0 nM -
CHEMBL2031509 IC50 > 100000.0 nM -
CHEMBL2031508 IC50 > 100000.0 nM -
CHEMBL2031512 IC50 > 100000.0 nM -
CHEMBL38396 IC50 = 106000.0 nM -
CHEMBL191476 IC50 > 100000.0 nM -
CHEMBL191011 IC50 > 100000.0 nM -
CHEMBL365348 IC50 > 100000.0 nM -
CHEMBL226544 IC50 > 100000.0 nM -
CHEMBL563557 BREVIANAMIDE F IC50 > 100000.0 nM -
CHEMBL190059 IC50 > 100000.0 nM -