Assay Detail
Binding
CHEMBL2067887
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Positive allosteric modulation activity at muscarinic M1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.41 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063422 | — | — | 1 | 7.39 |
| CHEMBL596507 | — | — | 1 | 7.08 |
| CHEMBL596508 | — | — | 1 | 6.57 |
| CHEMBL596506 | — | — | 1 | 6.42 |
| CHEMBL608112 | — | — | 1 | 6.09 |
| CHEMBL1083203 | — | — | 1 | 6.08 |
| CHEMBL523685 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063422 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL596507 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL596508 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL596506 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL608112 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1083203 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL523685 | — | EC50 | = | 6000.0 | nM | 5.22 |