Assay Detail
Functional
CHEMBL2076041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1641347) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.03 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 5.85 |
| CHEMBL1162495 | GLUTARATE | — | 1 | 5.31 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 5.20 |
| CHEMBL463 | AMINOHIPPURIC ACID | 4.0 | 1 | 5.06 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 4.55 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.22 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | - |
| CHEMBL316157 | CEPHALORIDINE | 4.0 | 1 | - |
| CHEMBL1604 | CEPHRADINE | 4.0 | 1 | - |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1162495 | GLUTARATE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL897 | PROBENECID | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL463 | AMINOHIPPURIC ACID | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL484 | ADEFOVIR | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | IC50 | = | 1100000.0 | nM | - |
| CHEMBL316157 | CEPHALORIDINE | IC50 | = | 1250000.0 | nM | - |
| CHEMBL1604 | CEPHRADINE | IC50 | = | 1600000.0 | nM | - |
| CHEMBL424 | SALICYLIC ACID | IC50 | = | 280000.0 | nM | - |