Assay Detail
Binding
CHEMBL2157385
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Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.97 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL2151432 | — | — | 2 | 8.30 |
| CHEMBL560590 | — | — | 1 | 7.48 |
| CHEMBL2151435 | — | — | 2 | 5.54 |
| CHEMBL2151043 | — | — | 2 | 4.08 |
| CHEMBL2151433 | — | — | 2 | 4.05 |
| CHEMBL2151434 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177577 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2151432 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2151432 | — | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL560590 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2151435 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2151435 | — | IC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL2151043 | — | IC50 | = | 82800.0 | nM | 4.08 |
| CHEMBL2151043 | — | IC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL2151433 | — | IC50 | = | 88600.0 | nM | 4.05 |
| CHEMBL2151433 | — | IC50 | = | 89125.09 | nM | 4.05 |
| CHEMBL2151434 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2151434 | — | IC50 | > | 316227.77 | nM | - |