Assay Detail
Binding
CHEMBL2208955
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Displacement of [3H]Spiperone from Sprague-Dawley rat dopamine D2-like receptor after 90 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.24 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 7.41 |
| CHEMBL495327 | — | — | 1 | 7.04 |
| CHEMBL2203404 | — | — | 1 | 6.25 |
| CHEMBL2203403 | — | — | 1 | 6.23 |
| CHEMBL2203405 | — | — | 1 | 6.14 |
| CHEMBL2203407 | — | — | 1 | 5.79 |
| CHEMBL2203406 | — | — | 1 | 5.59 |
| CHEMBL2203402 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL495327 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL2203404 | — | Ki | = | 564.0 | nM | 6.25 |
| CHEMBL2203403 | — | Ki | = | 584.0 | nM | 6.23 |
| CHEMBL2203405 | — | Ki | = | 725.0 | nM | 6.14 |
| CHEMBL2203407 | — | Ki | = | 1628.0 | nM | 5.79 |
| CHEMBL2203406 | — | Ki | = | 2568.0 | nM | 5.59 |
| CHEMBL2203402 | — | Ki | = | 3549.0 | nM | 5.45 |