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Assay Detail

CHEMBL2329694

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against blood stream stage of Trypanosoma brucei brucei after 48 hrs by Cell Titre Glo assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK.
J Med Chem (2013) 56 : 2850 -2860
PubMed 23484493 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 25 5.86 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2325781 1 6.54
CHEMBL2324301 1 6.43
CHEMBL2324302 1 6.40
CHEMBL2325223 1 6.28
CHEMBL2324306 1 6.27
CHEMBL2324303 1 6.27
CHEMBL2324296 1 6.19
CHEMBL2321911 1 6.02
CHEMBL2325222 1 6.02
CHEMBL2325778 1 6.01
CHEMBL2325779 1 5.96
CHEMBL2324304 1 5.92
CHEMBL2004817 1 5.80
CHEMBL2324295 1 5.75
CHEMBL2325224 1 5.75
CHEMBL2324305 1 5.68
CHEMBL2324297 1 5.55
CHEMBL2325784 1 5.51
CHEMBL2325785 1 5.39
CHEMBL2324298 1 5.38
CHEMBL2324299 1 5.31
CHEMBL2324300 1 5.21
CHEMBL2325783 1 5.21
CHEMBL2325782 1 -
CHEMBL2325780 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2325781 EC50 = 290.0 nM 6.54
CHEMBL2324301 EC50 = 370.0 nM 6.43
CHEMBL2324302 EC50 = 400.0 nM 6.40
CHEMBL2325223 EC50 = 520.0 nM 6.28
CHEMBL2324306 EC50 = 540.0 nM 6.27
CHEMBL2324303 EC50 = 540.0 nM 6.27
CHEMBL2324296 EC50 = 640.0 nM 6.19
CHEMBL2321911 EC50 = 950.0 nM 6.02
CHEMBL2325222 EC50 = 950.0 nM 6.02
CHEMBL2325778 EC50 = 980.0 nM 6.01
CHEMBL2325779 EC50 = 1100.0 nM 5.96
CHEMBL2324304 EC50 = 1200.0 nM 5.92
CHEMBL2004817 EC50 = 1600.0 nM 5.80
CHEMBL2324295 EC50 = 1800.0 nM 5.75
CHEMBL2325224 EC50 = 1800.0 nM 5.75
CHEMBL2324305 EC50 = 2100.0 nM 5.68
CHEMBL2324297 EC50 = 2800.0 nM 5.55
CHEMBL2325784 EC50 = 3100.0 nM 5.51
CHEMBL2325785 EC50 = 4100.0 nM 5.39
CHEMBL2324298 EC50 = 4200.0 nM 5.38
CHEMBL2324299 EC50 = 4900.0 nM 5.31
CHEMBL2324300 EC50 = 6100.0 nM 5.21
CHEMBL2325783 EC50 = 6100.0 nM 5.21
CHEMBL2325782 EC50 > 33000.0 nM -
CHEMBL2325780 EC50 > 33000.0 nM -