Assay Detail
Functional
CHEMBL2363167
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SANGER: Inhibition of human D-283MED cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | D283 Med |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.29 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.08 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.49 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.21 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.42 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.41 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.30 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.90 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.88 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.86 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.83 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.75 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.73 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.66 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.60 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.55 |
| CHEMBL217354 | — | — | 1 | 6.55 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.44 |
| CHEMBL512504 | — | — | 1 | 6.41 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.19 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.15 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.98 |
| CHEMBL577784 | BX-795 | — | 1 | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.95 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.91 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.66 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.65 |
| CHEMBL573107 | — | — | 1 | 5.65 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.084 | nM | 10.08 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.198 | nM | 8.49 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.239 | nM | 8.21 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 37.79 | nM | 7.42 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 40.85 | nM | 7.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 49.61 | nM | 7.30 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 126.98 | nM | 6.90 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 132.16 | nM | 6.88 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 136.87 | nM | 6.86 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 147.23 | nM | 6.83 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 176.86 | nM | 6.75 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 186.47 | nM | 6.73 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 220.69 | nM | 6.66 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 250.13 | nM | 6.60 |
| CHEMBL217354 | — | IC50 | = | 284.37 | nM | 6.55 |
| CHEMBL38 | TRETINOIN | IC50 | = | 282.62 | nM | 6.55 |
| CHEMBL803 | CYTARABINE | IC50 | = | 360.27 | nM | 6.44 |
| CHEMBL512504 | — | IC50 | = | 385.69 | nM | 6.41 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 642.84 | nM | 6.19 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 714.14 | nM | 6.15 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 835.31 | nM | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1051.9 | nM | 5.98 |
| CHEMBL577784 | BX-795 | IC50 | = | 1039.48 | nM | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1122.72 | nM | 5.95 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1223.79 | nM | 5.91 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2195.37 | nM | 5.66 |
| CHEMBL573107 | — | IC50 | = | 2236.95 | nM | 5.65 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 2247.82 | nM | 5.65 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 2359.26 | nM | 5.63 |
| CHEMBL585951 | — | IC50 | = | 2557.06 | nM | 5.59 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2724.3 | nM | 5.57 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 3189.37 | nM | 5.50 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3579.86 | nM | 5.45 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 3758.7 | nM | 5.42 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3812.18 | nM | 5.42 |
| CHEMBL2363137 | — | IC50 | = | 3958.34 | nM | 5.40 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4188.4 | nM | 5.38 |
| CHEMBL379975 | — | IC50 | = | 4463.69 | nM | 5.35 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 5310.99 | nM | 5.28 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 5847.57 | nM | 5.23 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 6176.33 | nM | 5.21 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 6863.72 | nM | 5.16 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7704.6 | nM | 5.11 |
| CHEMBL202721 | — | IC50 | = | 8608.92 | nM | 5.07 |
| CHEMBL64925 | MG-132 | IC50 | = | 8917.19 | nM | 5.05 |
| CHEMBL189584 | PD-173074 | IC50 | = | 9065.34 | nM | 5.04 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 9630.72 | nM | 5.02 |
| CHEMBL1190711 | — | IC50 | = | 10027.93 | nM | 5.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10495.93 | nM | 4.98 |