Assay Detail
Functional
CHEMBL2363228
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SANGER: Inhibition of human EW-3 cell growth in a cell viability assay.
120
Total Activities
119
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EW-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 120 | 5.65 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.50 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.13 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.51 |
| CHEMBL573107 | — | — | 1 | 7.45 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.43 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.40 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.39 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.34 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.31 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.21 |
| CHEMBL514499 | GW843682X | — | 1 | 7.18 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.09 |
| CHEMBL3349342 | — | — | 1 | 6.99 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.96 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.93 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.90 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.90 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.89 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.76 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.74 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.66 |
| CHEMBL300389 | — | — | 1 | 6.58 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.56 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.55 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.32 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.25 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.24 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 6.18 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.14 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.3192 | nM | 9.50 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.7448 | nM | 9.13 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 30.59 | nM | 7.51 |
| CHEMBL573107 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 37.21 | nM | 7.43 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 39.88 | nM | 7.40 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 40.56 | nM | 7.39 |
| CHEMBL939 | GEFITINIB | IC50 | = | 46.04 | nM | 7.34 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 49.17 | nM | 7.31 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 61.95 | nM | 7.21 |
| CHEMBL514499 | GW843682X | IC50 | = | 66.31 | nM | 7.18 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 80.53 | nM | 7.09 |
| CHEMBL3349342 | — | IC50 | = | 102.86 | nM | 6.99 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 109.8 | nM | 6.96 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 117.99 | nM | 6.93 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 126.61 | nM | 6.90 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 124.67 | nM | 6.90 |
| CHEMBL513909 | BI-2536 | IC50 | = | 128.93 | nM | 6.89 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 174.86 | nM | 6.76 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 182.23 | nM | 6.74 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 217.18 | nM | 6.66 |
| CHEMBL300389 | — | IC50 | = | 260.85 | nM | 6.58 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 274.73 | nM | 6.56 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 279.89 | nM | 6.55 |
| CHEMBL38 | TRETINOIN | IC50 | = | 480.28 | nM | 6.32 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 559.35 | nM | 6.25 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 579.56 | nM | 6.24 |
| CHEMBL1090090 | VX-702 | IC50 | = | 666.11 | nM | 6.18 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 721.5 | nM | 6.14 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 735.52 | nM | 6.13 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 808.76 | nM | 6.09 |
| CHEMBL803 | CYTARABINE | IC50 | = | 829.99 | nM | 6.08 |
| CHEMBL379975 | — | IC50 | = | 946.79 | nM | 6.02 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1016.16 | nM | 5.99 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1078.83 | nM | 5.97 |
| CHEMBL379300 | A-443654 | IC50 | = | 1113.46 | nM | 5.95 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1172.12 | nM | 5.93 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 1597.58 | nM | 5.80 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 2098.44 | nM | 5.68 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 2275.34 | nM | 5.64 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 2925.05 | nM | 5.53 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 3195.29 | nM | 5.50 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3409.5 | nM | 5.47 |
| CHEMBL477989 | SB590885 | IC50 | = | 3557.8 | nM | 5.45 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3514.36 | nM | 5.45 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 3579.35 | nM | 5.45 |
| CHEMBL189584 | PD-173074 | IC50 | = | 3989.23 | nM | 5.40 |
| CHEMBL585951 | — | IC50 | = | 4233.09 | nM | 5.37 |
| CHEMBL202721 | — | IC50 | = | 4453.81 | nM | 5.35 |
| CHEMBL509032 | TAE-684 | IC50 | = | 4762.48 | nM | 5.32 |