Assay Detail
Functional
CHEMBL2363245
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SANGER: Inhibition of human GOTO cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GOTO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.37 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.15 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.64 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.09 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.77 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.73 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.51 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.30 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.15 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.14 |
| CHEMBL300389 | — | — | 1 | 7.12 |
| CHEMBL217354 | — | — | 1 | 6.77 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.76 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.60 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.55 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.54 |
| CHEMBL514499 | GW843682X | — | 1 | 6.48 |
| CHEMBL379300 | A-443654 | — | 1 | 6.44 |
| CHEMBL512504 | — | — | 1 | 6.40 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.38 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.37 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.34 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.26 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.26 |
| CHEMBL379975 | — | — | 1 | 6.18 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.14 |
| CHEMBL585951 | — | — | 1 | 6.09 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.03 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.02 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.7058 | nM | 9.15 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.207 | nM | 8.09 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 17.06 | nM | 7.77 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 18.65 | nM | 7.73 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 50.52 | nM | 7.30 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 70.54 | nM | 7.15 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 73.03 | nM | 7.14 |
| CHEMBL300389 | — | IC50 | = | 74.92 | nM | 7.12 |
| CHEMBL217354 | — | IC50 | = | 170.95 | nM | 6.77 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 172.46 | nM | 6.76 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 207.3 | nM | 6.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 250.29 | nM | 6.60 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 278.94 | nM | 6.55 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 285.56 | nM | 6.54 |
| CHEMBL514499 | GW843682X | IC50 | = | 333.16 | nM | 6.48 |
| CHEMBL379300 | A-443654 | IC50 | = | 366.19 | nM | 6.44 |
| CHEMBL512504 | — | IC50 | = | 395.36 | nM | 6.40 |
| CHEMBL513909 | BI-2536 | IC50 | = | 421.18 | nM | 6.38 |
| CHEMBL803 | CYTARABINE | IC50 | = | 424.03 | nM | 6.37 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 451.6 | nM | 6.34 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 549.93 | nM | 6.26 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 553.71 | nM | 6.26 |
| CHEMBL379975 | — | IC50 | = | 666.24 | nM | 6.18 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 729.12 | nM | 6.14 |
| CHEMBL585951 | — | IC50 | = | 809.41 | nM | 6.09 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 940.24 | nM | 6.03 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 950.76 | nM | 6.02 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1095.24 | nM | 5.96 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1215.9 | nM | 5.92 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1202.77 | nM | 5.92 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1735.6 | nM | 5.76 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1958.32 | nM | 5.71 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2053.52 | nM | 5.69 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 2530.13 | nM | 5.60 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2653.48 | nM | 5.58 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 2653.77 | nM | 5.58 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3088.58 | nM | 5.51 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3220.39 | nM | 5.49 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 3304.14 | nM | 5.48 |
| CHEMBL573107 | — | IC50 | = | 3280.04 | nM | 5.48 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3417.32 | nM | 5.47 |
| CHEMBL1190711 | — | IC50 | = | 3422.69 | nM | 5.47 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3843.33 | nM | 5.42 |
| CHEMBL188678 | — | IC50 | = | 3914.9 | nM | 5.41 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4297.05 | nM | 5.37 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 4588.35 | nM | 5.34 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4792.93 | nM | 5.32 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5495.76 | nM | 5.26 |