Assay Detail
Functional
CHEMBL2363249
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SANGER: Inhibition of human H-EMC-SS cell growth in a cell viability assay.
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H-EMC-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.67 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.43 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.96 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.02 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 6.96 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.84 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.83 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.59 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.55 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.54 |
| CHEMBL189584 | PD-173074 | — | 1 | 6.46 |
| CHEMBL477989 | SB590885 | — | 1 | 6.45 |
| CHEMBL217354 | — | — | 1 | 6.42 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.37 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.30 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.15 |
| CHEMBL176544 | — | — | 1 | 6.12 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.11 |
| CHEMBL3349342 | — | — | 1 | 6.04 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.89 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.59 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.45 |
| CHEMBL379975 | — | — | 1 | 5.43 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.37 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 5.20 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.20 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.18 |
| CHEMBL577784 | BX-795 | — | 1 | 5.03 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 1 | 5.03 |
| CHEMBL399530 | — | — | 1 | 5.00 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 3.684 | nM | 8.43 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 95.58 | nM | 7.02 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 110.05 | nM | 6.96 |
| CHEMBL803 | CYTARABINE | IC50 | = | 145.28 | nM | 6.84 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 146.81 | nM | 6.83 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 255.94 | nM | 6.59 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 283.54 | nM | 6.55 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 290.99 | nM | 6.54 |
| CHEMBL189584 | PD-173074 | IC50 | = | 347.15 | nM | 6.46 |
| CHEMBL477989 | SB590885 | IC50 | = | 351.31 | nM | 6.45 |
| CHEMBL217354 | — | IC50 | = | 378.23 | nM | 6.42 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 425.32 | nM | 6.37 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 499.39 | nM | 6.30 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 705.46 | nM | 6.15 |
| CHEMBL176544 | — | IC50 | = | 764.86 | nM | 6.12 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 770.51 | nM | 6.11 |
| CHEMBL3349342 | — | IC50 | = | 917.03 | nM | 6.04 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1296.08 | nM | 5.89 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2546.5 | nM | 5.59 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3585.69 | nM | 5.45 |
| CHEMBL379975 | — | IC50 | = | 3698.58 | nM | 5.43 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4318.31 | nM | 5.37 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 6339.13 | nM | 5.20 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 6386.0 | nM | 5.20 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 6561.47 | nM | 5.18 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 9327.27 | nM | 5.03 |
| CHEMBL577784 | BX-795 | IC50 | = | 9395.58 | nM | 5.03 |
| CHEMBL399530 | — | IC50 | = | 9968.57 | nM | 5.00 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 13913.95 | nM | 4.86 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 13910.36 | nM | 4.86 |
| CHEMBL393929 | — | IC50 | = | 19435.94 | nM | 4.71 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 20774.97 | nM | 4.68 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 21155.5 | nM | 4.67 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 22045.05 | nM | 4.66 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 26411.38 | nM | 4.58 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 26924.48 | nM | 4.57 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 32967.82 | nM | 4.48 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 38280.4 | nM | 4.42 |
| CHEMBL939 | GEFITINIB | IC50 | = | 45769.27 | nM | 4.34 |
| CHEMBL1186585 | — | IC50 | = | 47027.95 | nM | 4.33 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 48322.44 | nM | 4.32 |
| CHEMBL255342 | — | IC50 | = | 490883.58 | nM | - |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 115603.82 | nM | - |
| CHEMBL2134202 | — | IC50 | = | 184761.54 | nM | - |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 189390.69 | nM | - |
| CHEMBL1431 | METFORMIN | IC50 | = | 25518552.1 | nM | - |
| CHEMBL202721 | — | IC50 | = | 115083.85 | nM | - |
| CHEMBL210618 | — | IC50 | = | 151872.14 | nM | - |
| CHEMBL573107 | — | IC50 | = | 202692.49 | nM | - |