Assay Detail
Functional
CHEMBL2363304
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SANGER: Inhibition of human HuO9 cell growth in a cell viability assay.
75
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuO9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 5.60 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.54 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.46 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.15 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.90 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.67 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.57 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.26 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.12 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.75 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.69 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.57 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.53 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.39 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.36 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.25 |
| CHEMBL585951 | — | — | 1 | 6.20 |
| CHEMBL217354 | — | — | 1 | 6.14 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.03 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.03 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.88 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.84 |
| CHEMBL258844 | — | — | 1 | 5.81 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.79 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.78 |
| CHEMBL379975 | — | — | 1 | 5.71 |
| CHEMBL573107 | — | — | 1 | 5.63 |
| CHEMBL577784 | BX-795 | — | 1 | 5.59 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 5.46 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.41 |
| CHEMBL399530 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.881 | nM | 8.54 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.456 | nM | 8.46 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.092 | nM | 8.15 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.64 | nM | 7.90 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 21.54 | nM | 7.67 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 26.76 | nM | 7.57 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 54.48 | nM | 7.26 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 75.89 | nM | 7.12 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 177.44 | nM | 6.75 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 206.02 | nM | 6.69 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 267.15 | nM | 6.57 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 297.93 | nM | 6.53 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 406.67 | nM | 6.39 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 441.35 | nM | 6.36 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 560.66 | nM | 6.25 |
| CHEMBL585951 | — | IC50 | = | 638.45 | nM | 6.20 |
| CHEMBL217354 | — | IC50 | = | 727.4 | nM | 6.14 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 925.78 | nM | 6.03 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 927.51 | nM | 6.03 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1327.94 | nM | 5.88 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1453.62 | nM | 5.84 |
| CHEMBL258844 | — | IC50 | = | 1553.11 | nM | 5.81 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1612.8 | nM | 5.79 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1658.0 | nM | 5.78 |
| CHEMBL379975 | — | IC50 | = | 1957.95 | nM | 5.71 |
| CHEMBL573107 | — | IC50 | = | 2368.24 | nM | 5.63 |
| CHEMBL577784 | BX-795 | IC50 | = | 2564.56 | nM | 5.59 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 3506.48 | nM | 5.46 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3853.47 | nM | 5.41 |
| CHEMBL399530 | — | IC50 | = | 4005.92 | nM | 5.40 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 4174.33 | nM | 5.38 |
| CHEMBL189584 | PD-173074 | IC50 | = | 5388.43 | nM | 5.27 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 5645.38 | nM | 5.25 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 6664.77 | nM | 5.18 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 6739.64 | nM | 5.17 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 7487.94 | nM | 5.13 |
| CHEMBL188678 | — | IC50 | = | 7717.43 | nM | 5.11 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 12066.57 | nM | 4.92 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 11877.42 | nM | 4.92 |
| CHEMBL512504 | — | IC50 | = | 14444.63 | nM | 4.84 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 15062.98 | nM | 4.82 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 17703.1 | nM | 4.75 |
| CHEMBL105442 | CI-1040 | IC50 | = | 19137.87 | nM | 4.72 |
| CHEMBL38 | TRETINOIN | IC50 | = | 19315.79 | nM | 4.71 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 21562.33 | nM | 4.67 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 21982.46 | nM | 4.66 |
| CHEMBL939 | GEFITINIB | IC50 | = | 22739.58 | nM | 4.64 |
| CHEMBL202721 | — | IC50 | = | 23474.18 | nM | 4.63 |
| CHEMBL222102 | KU-55933 | IC50 | = | 32528.19 | nM | 4.49 |
| CHEMBL3349342 | — | IC50 | = | 36843.49 | nM | 4.43 |