Assay Detail
Functional
CHEMBL2363309
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SANGER: Inhibition of human IGROV-1 cell growth in a cell viability assay.
96
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 96 | 5.98 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.22 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.84 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.81 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.14 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.09 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.41 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.25 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.16 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.14 |
| CHEMBL585951 | — | — | 1 | 7.01 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.98 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.97 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.87 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.84 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.77 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.73 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.68 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.67 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.64 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.61 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.59 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.47 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.46 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.34 |
| CHEMBL217354 | — | — | 1 | 6.34 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.31 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.0607 | nM | 10.22 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.145 | nM | 9.84 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.156 | nM | 9.81 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.202 | nM | 8.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 6.002 | nM | 8.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.205 | nM | 8.14 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 8.136 | nM | 8.09 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 36.34 | nM | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 38.79 | nM | 7.41 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 55.61 | nM | 7.25 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 68.57 | nM | 7.16 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 72.48 | nM | 7.14 |
| CHEMBL585951 | — | IC50 | = | 97.74 | nM | 7.01 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 103.98 | nM | 6.98 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 105.97 | nM | 6.97 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 135.76 | nM | 6.87 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 144.55 | nM | 6.84 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 170.72 | nM | 6.77 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 184.43 | nM | 6.73 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 208.23 | nM | 6.68 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 215.27 | nM | 6.67 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 228.32 | nM | 6.64 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 244.01 | nM | 6.61 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 259.52 | nM | 6.59 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 337.55 | nM | 6.47 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 343.31 | nM | 6.46 |
| CHEMBL217354 | — | IC50 | = | 453.62 | nM | 6.34 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 451.99 | nM | 6.34 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 487.97 | nM | 6.31 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 552.49 | nM | 6.26 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 567.2 | nM | 6.25 |
| CHEMBL191384 | — | IC50 | = | 603.48 | nM | 6.22 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 634.31 | nM | 6.20 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 674.5 | nM | 6.17 |
| CHEMBL258844 | — | IC50 | = | 723.28 | nM | 6.14 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 810.38 | nM | 6.09 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1154.44 | nM | 5.94 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1335.79 | nM | 5.87 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1693.17 | nM | 5.77 |
| CHEMBL3349342 | — | IC50 | = | 1779.83 | nM | 5.75 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1789.89 | nM | 5.75 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1974.1 | nM | 5.71 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2312.37 | nM | 5.64 |
| CHEMBL1090090 | VX-702 | IC50 | = | 2431.88 | nM | 5.61 |
| CHEMBL1190711 | — | IC50 | = | 2530.69 | nM | 5.60 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2548.28 | nM | 5.59 |
| CHEMBL2363137 | — | IC50 | = | 2655.94 | nM | 5.58 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 3247.13 | nM | 5.49 |
| CHEMBL379975 | — | IC50 | = | 3887.27 | nM | 5.41 |
| CHEMBL105442 | CI-1040 | IC50 | = | 4451.71 | nM | 5.35 |