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Assay Detail

CHEMBL2363592

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Functional
SANGER: Inhibition of human PSN1 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PSN1
Confidence 1 — Organism
Curated By Autocuration

Target

PSN1 (CHEMBL614241) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.84 10.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.78
CHEMBL96926 THAPSIGARGIN — 1 10.17
CHEMBL94657 PATUPILONE 3.0 1 9.76
CHEMBL3545252 DOCETAXEL 4.0 1 9.23
CHEMBL325041 BORTEZOMIB 3.0 1 8.99
CHEMBL159 VINBLASTINE 4.0 1 8.90
CHEMBL428647 PACLITAXEL 4.0 1 8.89
CHEMBL105 MITOMYCIN 4.0 1 8.59
CHEMBL65 CAMPTOTHECIN -1.0 1 8.51
CHEMBL252164 LUMINESPIB 2.0 1 8.50
CHEMBL1972860 ELESCLOMOL 3.0 1 8.42
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 8.33
CHEMBL514499 GW843682X — 1 8.23
CHEMBL513909 BI-2536 2.0 1 8.11
CHEMBL53463 DOXORUBICIN 4.0 1 7.95
CHEMBL1256459 TORIN1 — 1 7.85
CHEMBL300389 — — 1 7.82
CHEMBL2144069 — — 1 7.56
CHEMBL507361 MIRDAMETINIB 2.0 1 7.42
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.36
CHEMBL5416410 DASATINIB 4.0 1 7.35
CHEMBL1879463 DACTOLISIB 3.0 1 7.35
CHEMBL109480 TANESPIMYCIN 3.0 1 7.34
CHEMBL379300 A-443654 — 1 7.33
CHEMBL575448 BMS-754807 2.0 1 7.11
CHEMBL6067492 BLEOMYCIN 4.0 1 6.86
CHEMBL217354 — — 1 6.78
CHEMBL509032 TAE-684 — 1 6.71
CHEMBL803 CYTARABINE 4.0 1 6.71
CHEMBL3349342 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.01652 nM 10.78
CHEMBL96926 THAPSIGARGIN IC50 = 0.06693 nM 10.17
CHEMBL94657 PATUPILONE IC50 = 0.1731 nM 9.76
CHEMBL3545252 DOCETAXEL IC50 = 0.5815 nM 9.23
CHEMBL325041 BORTEZOMIB IC50 = 1.011 nM 8.99
CHEMBL159 VINBLASTINE IC50 = 1.248 nM 8.90
CHEMBL428647 PACLITAXEL IC50 = 1.301 nM 8.89
CHEMBL105 MITOMYCIN IC50 = 2.554 nM 8.59
CHEMBL65 CAMPTOTHECIN IC50 = 3.069 nM 8.51
CHEMBL252164 LUMINESPIB IC50 = 3.18 nM 8.50
CHEMBL1972860 ELESCLOMOL IC50 = 3.841 nM 8.42
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 4.669 nM 8.33
CHEMBL514499 GW843682X IC50 = 5.826 nM 8.23
CHEMBL513909 BI-2536 IC50 = 7.76 nM 8.11
CHEMBL53463 DOXORUBICIN IC50 = 11.22 nM 7.95
CHEMBL1256459 TORIN1 IC50 = 14.09 nM 7.85
CHEMBL300389 — IC50 = 15.18 nM 7.82
CHEMBL2144069 — IC50 = 27.37 nM 7.56
CHEMBL507361 MIRDAMETINIB IC50 = 38.45 nM 7.42
CHEMBL449158 BRYOSTATIN 1 IC50 = 43.76 nM 7.36
CHEMBL1879463 DACTOLISIB IC50 = 44.4 nM 7.35
CHEMBL5416410 DASATINIB IC50 = 44.74 nM 7.35
CHEMBL109480 TANESPIMYCIN IC50 = 46.03 nM 7.34
CHEMBL379300 A-443654 IC50 = 47.29 nM 7.33
CHEMBL575448 BMS-754807 IC50 = 78.22 nM 7.11
CHEMBL6067492 BLEOMYCIN IC50 = 138.88 nM 6.86
CHEMBL217354 — IC50 = 167.24 nM 6.78
CHEMBL509032 TAE-684 IC50 = 196.31 nM 6.71
CHEMBL803 CYTARABINE IC50 = 192.81 nM 6.71
CHEMBL3349342 — IC50 = 198.21 nM 6.70
CHEMBL572878 TOZASERTIB IC50 = 220.26 nM 6.66
CHEMBL603469 LESTAURTINIB IC50 = 231.05 nM 6.64
CHEMBL413 SIROLIMUS IC50 = 242.71 nM 6.62
CHEMBL1614701 SELUMETINIB IC50 = 366.09 nM 6.44
CHEMBL1201182 TEMSIROLIMUS IC50 = 387.25 nM 6.41
CHEMBL401930 — IC50 = 395.47 nM 6.40
CHEMBL2041933 AZD-7762 IC50 = 591.18 nM 6.23
CHEMBL1801204 AZD-8055 IC50 = 770.57 nM 6.11
CHEMBL1190711 — IC50 = 897.08 nM 6.05
CHEMBL105442 CI-1040 IC50 = 961.96 nM 6.02
CHEMBL289228 TIPIFARNIB IC50 = 1111.97 nM 5.95
CHEMBL197603 — IC50 = 1137.87 nM 5.94
CHEMBL64925 MG-132 IC50 = 1270.16 nM 5.90
CHEMBL27759 ENTINOSTAT IC50 = 1422.87 nM 5.85
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1494.27 nM 5.83
CHEMBL535 SUNITINIB IC50 = 1506.76 nM 5.82
CHEMBL34259 METHOTREXATE IC50 = 1586.64 nM 5.80
CHEMBL11359 CISPLATIN IC50 = 1675.44 nM 5.78
CHEMBL477989 SB590885 IC50 = 1873.36 nM 5.73
CHEMBL558642 GSK-650394 IC50 = 2185.5 nM 5.66