Assay Detail
Functional
CHEMBL2363724
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SANGER: Inhibition of human A2780 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.85 | 9.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.71 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.57 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 9.23 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.68 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.54 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.47 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.23 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.20 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.68 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.60 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.26 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.03 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.97 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.97 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.79 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.68 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.66 |
| CHEMBL217354 | — | — | 1 | 6.66 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.46 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.37 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.32 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.30 |
| CHEMBL585951 | — | — | 1 | 6.18 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.06 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL1190711 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1964 | nM | 9.71 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.2702 | nM | 9.57 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 0.5939 | nM | 9.23 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.902 | nM | 8.54 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.353 | nM | 8.47 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.608 | nM | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 5.882 | nM | 8.23 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.382 | nM | 8.20 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.15 | nM | 7.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 20.79 | nM | 7.68 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 25.31 | nM | 7.60 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 54.54 | nM | 7.26 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 68.79 | nM | 7.16 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 94.02 | nM | 7.03 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 106.47 | nM | 6.97 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 106.63 | nM | 6.97 |
| CHEMBL803 | CYTARABINE | IC50 | = | 162.38 | nM | 6.79 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 209.89 | nM | 6.68 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 220.19 | nM | 6.66 |
| CHEMBL217354 | — | IC50 | = | 218.46 | nM | 6.66 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 343.04 | nM | 6.46 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 431.62 | nM | 6.37 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 475.03 | nM | 6.32 |
| CHEMBL105442 | CI-1040 | IC50 | = | 498.23 | nM | 6.30 |
| CHEMBL585951 | — | IC50 | = | 653.01 | nM | 6.18 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 863.27 | nM | 6.06 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1011.46 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1105.27 | nM | 5.96 |
| CHEMBL1190711 | — | IC50 | = | 1525.48 | nM | 5.82 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1722.07 | nM | 5.76 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 1940.89 | nM | 5.71 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 2062.94 | nM | 5.69 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2562.45 | nM | 5.59 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2559.0 | nM | 5.59 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3103.41 | nM | 5.51 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3304.8 | nM | 5.48 |
| CHEMBL135561 | — | IC50 | = | 3515.69 | nM | 5.45 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3640.89 | nM | 5.44 |
| CHEMBL399530 | — | IC50 | = | 3754.94 | nM | 5.42 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4059.66 | nM | 5.39 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4366.82 | nM | 5.36 |
| CHEMBL2363137 | — | IC50 | = | 5494.65 | nM | 5.26 |
| CHEMBL1186585 | — | IC50 | = | 6381.61 | nM | 5.20 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 6377.01 | nM | 5.20 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6388.63 | nM | 5.20 |
| CHEMBL591429 | PAC-1 | IC50 | = | 7619.86 | nM | 5.12 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 8352.56 | nM | 5.08 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 8764.48 | nM | 5.06 |
| CHEMBL577784 | BX-795 | IC50 | = | 9180.48 | nM | 5.04 |