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Assay Detail

CHEMBL2390228

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum after 15 mins by liquid scintillation counting analysis
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL339) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Chen Y, Wang S, Xu X, Liu X, Yu M, Zhao S, Liu S, Qiu Y, Zhang T, Liu BF, Zhang G.
J Med Chem (2013) 56 : 4671 -4690
PubMed 23675993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 45 6.85 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2387253 — — 1 8.85
CHEMBL2387229 — — 1 8.59
CHEMBL85 RISPERIDONE 4.0 1 8.43
CHEMBL2387245 — — 1 8.41
CHEMBL2385102 — — 1 8.40
CHEMBL2387260 — — 1 8.31
CHEMBL2387230 — — 1 8.28
CHEMBL2387233 — — 1 7.97
CHEMBL2387265 — — 1 7.83
CHEMBL2387239 — — 1 7.77
CHEMBL2387249 — — 1 7.35
CHEMBL2387237 — — 1 6.93
CHEMBL2387227 — — 1 6.92
CHEMBL2387238 — — 1 6.91
CHEMBL42 CLOZAPINE 4.0 1 6.89
CHEMBL2387256 — — 1 6.85
CHEMBL2387254 — — 1 6.81
CHEMBL2387259 — — 1 6.75
CHEMBL2387251 — — 1 6.74
CHEMBL2387262 — — 1 6.62
CHEMBL2387255 — — 1 6.38
CHEMBL2387232 — — 1 6.34
CHEMBL2387242 — — 1 6.29
CHEMBL2387250 — — 1 6.25
CHEMBL2387234 — — 1 6.20
CHEMBL2387235 — — 1 6.10
CHEMBL2387228 — — 1 6.07
CHEMBL2387241 — — 1 6.01
CHEMBL2387257 — — 1 5.86
CHEMBL2387252 — — 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2387253 — Ki = 1.4 nM 8.85
CHEMBL2387229 — Ki = 2.6 nM 8.59
CHEMBL85 RISPERIDONE Ki = 3.7 nM 8.43
CHEMBL2387245 — Ki = 3.9 nM 8.41
CHEMBL2385102 — Ki = 4.0 nM 8.40
CHEMBL2387260 — Ki = 4.9 nM 8.31
CHEMBL2387230 — Ki = 5.3 nM 8.28
CHEMBL2387233 — Ki = 10.7 nM 7.97
CHEMBL2387265 — Ki = 14.8 nM 7.83
CHEMBL2387239 — Ki = 17.1 nM 7.77
CHEMBL2387249 — Ki = 44.9 nM 7.35
CHEMBL2387237 — Ki = 116.3 nM 6.93
CHEMBL2387227 — Ki = 119.1 nM 6.92
CHEMBL2387238 — Ki = 122.8 nM 6.91
CHEMBL42 CLOZAPINE Ki = 128.7 nM 6.89
CHEMBL2387256 — Ki = 142.6 nM 6.85
CHEMBL2387254 — Ki = 156.3 nM 6.81
CHEMBL2387259 — Ki = 176.3 nM 6.75
CHEMBL2387251 — Ki = 182.4 nM 6.74
CHEMBL2387262 — Ki = 241.9 nM 6.62
CHEMBL2387255 — Ki = 412.1 nM 6.38
CHEMBL2387232 — Ki = 459.3 nM 6.34
CHEMBL2387242 — Ki = 515.2 nM 6.29
CHEMBL2387250 — Ki = 568.7 nM 6.25
CHEMBL2387234 — Ki = 631.6 nM 6.20
CHEMBL2387235 — Ki = 786.8 nM 6.10
CHEMBL2387228 — Ki = 843.6 nM 6.07
CHEMBL2387241 — Ki = 987.3 nM 6.01
CHEMBL2387257 — Ki = 1385.4 nM 5.86
CHEMBL2387252 — Ki = 1589.6 nM 5.80
CHEMBL2387258 — Ki = 1868.7 nM 5.73
CHEMBL2387244 — Ki = 1928.6 nM 5.71
CHEMBL2387236 — Ki = 2348.8 nM 5.63
CHEMBL2387246 — Ki = 2350.3 nM 5.63
CHEMBL2387248 — Ki = 2817.2 nM 5.55
CHEMBL2387267 — Ki = 3012.4 nM 5.52
CHEMBL2387240 — Ki > 10000.0 nM -
CHEMBL2387263 — Ki > 10000.0 nM -
CHEMBL2387231 — Ki > 10000.0 nM -
CHEMBL2387226 — Ki > 10000.0 nM -
CHEMBL2387261 — Ki > 10000.0 nM -
CHEMBL2387247 — Ki > 10000.0 nM -
CHEMBL2387243 — Ki > 10000.0 nM -
CHEMBL2387266 — Ki > 10000.0 nM -
CHEMBL2387264 — Ki > 10000.0 nM -