Assay Detail
Functional
CHEMBL2432617
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Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition measured on day 5 by spectrophotometry
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Computational POM evaluation of experimental in vitro Trypanosoma cruzi and Mycobacterium tuberculosis inhibition of heterocyclic-2-carboxylic acid (3-cyano-1,4-di-noxidequinoxalin-2-yl)amide derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.85 | 4.97 |
| MIC | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1209417 | — | — | 1 | 4.97 |
| CHEMBL1209416 | — | — | 1 | 4.72 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1209417 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1209416 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL290960 | NIFURTIMOX | MIC | = | 7700.0 | nM | - |