Assay Detail
Binding
CHEMBL3049784
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Inhibition of Zea mays (maize) microsomal delta 8,14-steroid 14-reductase using delta 8,14-cholestadienol as substrate after 90 min by GC analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.13 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2253388 | — | — | 1 | 7.52 |
| CHEMBL2253390 | — | — | 1 | 7.16 |
| CHEMBL17413 | — | — | 1 | 7.10 |
| CHEMBL279569 | — | — | 1 | 7.05 |
| CHEMBL17470 | — | — | 1 | 6.52 |
| CHEMBL372700 | FENPROPIMORPH | — | 1 | 6.10 |
| CHEMBL1889041 | FENPROPIDIN | -1.0 | 1 | 5.52 |
| CHEMBL333562 | — | — | 1 | 5.35 |
| CHEMBL2286765 | TRIDEMORPH | — | 1 | 4.60 |
| CHEMBL3215942 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2253388 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2253390 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL17413 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL279569 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL17470 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL372700 | FENPROPIMORPH | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1889041 | FENPROPIDIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL333562 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2286765 | TRIDEMORPH | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3215942 | — | IC50 | = | 40000.0 | nM | 4.40 |