Compound Detail
CHEMBL1889041
FENPROPIDIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1889041 |
| Name | FENPROPIDIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MGNFYQILYYYUBS-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
15
Publications
2
Known Names
Molecular Properties
273.5
MW (Da)
4.65
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 3 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol-8,7-isomerase CHEMBL2366492 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Cycloeucalenol cycloisomerase CHEMBL2366413 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Delta(14)-sterol reductase CHEMBL2366411 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol-8,7-isomerase | IC50 | = | 80.0 | nM | 7.1 | Inhibition of Zea mays (maize) delta8,delta7-sterol isomerase | 2591378 |
| Cycloeucalenol cycloisomerase | IC50 | = | 200.0 | nM | 6.7 | Inhibition of Zea mays (maize) cycloeucalenol-obtusifolial isomerase | 2591378 |
| Delta(14)-sterol reductase | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of Zea mays (maize) microsomal delta 8,14-steroid 14-reductase using ... | 2591378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Candida albicans | 6 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Cryptococcus neoformans | 3 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Nakaseomyces glabratus | 3 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Candida tropicalis | 3 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Aspergillus niger | 3 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | ADMET | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 2591378 | 10.1111/j.1432-1033.1989.tb15156.x | Sterol-8,7-isomerase | 1 |
| 2591378 | 10.1111/j.1432-1033.1989.tb15156.x | Cycloeucalenol cycloisomerase | 1 |
| 2591378 | 10.1111/j.1432-1033.1989.tb15156.x | Delta(14)-sterol reductase | 1 |
| - | 10.1584/jpestics.G09-12 | Blumeria graminis | 1 |
| - | 10.1584/jpestics.G09-12 | Puccinia recondita | 1 |
| - | 10.1584/jpestics.G09-12 | Pseudoperonospora cubensis | 1 |
| - | 10.1584/jpestics.G09-12 | Botrytis cinerea | 1 |
| 26617963 | 10.1021/acsmedchemlett.5b00245 | Liver microsome | 1 |
Data from ChEMBL 36 via Core Engine