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Assay Detail

CHEMBL3056594

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Functional
Antimicrobial activity against Pneumocystis carinii assessed as ATP level detection by bioluminescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Pneumocystis carinii
Confidence 1 — Organism
Curated By Autocuration

Target

Pneumocystis carinii (CHEMBL613064)
Type ORGANISM
Organism Pneumocystis carinii

Publication

Antitumor and Anti-Pneumocystis Carinii Activities of Novel Bisbenzamidines
Vanden Eynde JJ, Mayence A, Johnson MT, Huang TL, Collins MS, Rebholz S, Walzer PD, Cushion MT, Donkor IO
Med Chem Res (2005) 14 : 143 -157
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.07 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185175 1 8.70
CHEMBL185063 1 8.52
CHEMBL535205 1 7.04
CHEMBL9053 1 6.45
CHEMBL55 PENTAMIDINE 4.0 1 6.30
CHEMBL9391 1 5.92
CHEMBL9025 1 5.85
CHEMBL185172 1 5.77
CHEMBL269032 1 5.70
CHEMBL9126 1 5.58
CHEMBL249456 1 5.58
CHEMBL537055 1 5.52
CHEMBL88670 1 5.35
CHEMBL586743 1 5.27
CHEMBL183814 BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE 1 4.87
CHEMBL142952 1 4.64
CHEMBL1946713 1 -
CHEMBL24029 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185175 IC50 = 2.0 nM 8.70
CHEMBL185063 IC50 = 3.0 nM 8.52
CHEMBL535205 IC50 = 91.0 nM 7.04
CHEMBL9053 IC50 = 357.0 nM 6.45
CHEMBL55 PENTAMIDINE IC50 = 500.0 nM 6.30
CHEMBL9391 IC50 = 1200.0 nM 5.92
CHEMBL9025 IC50 = 1400.0 nM 5.85
CHEMBL185172 IC50 = 1700.0 nM 5.77
CHEMBL269032 IC50 = 2000.0 nM 5.70
CHEMBL9126 IC50 = 2600.0 nM 5.58
CHEMBL249456 IC50 = 2600.0 nM 5.58
CHEMBL537055 IC50 = 3000.0 nM 5.52
CHEMBL88670 IC50 = 4500.0 nM 5.35
CHEMBL586743 IC50 = 5400.0 nM 5.27
CHEMBL183814 BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE IC50 = 13400.0 nM 4.87
CHEMBL142952 IC50 = 22800.0 nM 4.64
CHEMBL1946713 IC50 > 125000.0 nM -
CHEMBL24029 IC50 - -