Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL88670

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
c1cc(N2CCCN(c3ccc(C4=NCCCN4)cc3)CC2)ccc1C1=NCCCN1

Basic Information

ChEMBL ID CHEMBL88670
Phase Preclinical
Structure Type MOL
InChI Key KDOAVCHLHBJIOD-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

416.6
MW (Da)
2.88
ALogP
6
HBA
2
HBD
55.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H32N6
MW 416.57
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.64

Activity Summary

IC50 3 meas. best 5.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Pneumocystis carinii
CHEMBL613064
IC50 5.35 5.35 4500.0 1
Glutamate NMDA receptor
CHEMBL1907608
IC50 4.89 4.89 12800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26117647 10.1016/j.bmc.2015.06.012 Glutamate NMDA receptor 4
11591500 10.1016/s0960-894x(01)00541-8 Pneumocystis carinii 2
- 10.1007/s00044-005-0130-2 Unchecked 2
11591500 10.1016/s0960-894x(01)00541-8 Nucleic Acid 1
11591500 10.1016/s0960-894x(01)00541-8 Unchecked 1
- 10.1007/s00044-005-0130-2 SN12C 1
- 10.1007/s00044-005-0130-2 A498 1
- 10.1007/s00044-005-0130-2 DNA 1
- 10.1007/s00044-005-0130-2 MCF7 1
- 10.1007/s00044-005-0130-2 SF-268 1
- 10.1007/s00044-005-0130-2 NCI-H460 1
- 10.1007/s00044-005-0130-2 Pneumocystis carinii 1

Data from ChEMBL 36 via Core Engine