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Compound Detail

CHEMBL535205

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CCCC/N=C(/N)c1ccc(N2CCN(c3ccc(/C(N)=N\CCCC)cc3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL535205
Phase Preclinical
Structure Type MOL
InChI Key MUJHQBQAGZJGTP-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

434.6
MW (Da)
4.02
ALogP
4
HBA
2
HBD
83.2
PSA (Ų)
0.34
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H38N6
MW 434.63
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness -0.52

Activity Summary

IC50 3 meas. best 7.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Pneumocystis carinii
CHEMBL613064
IC50 7.04 7.04 91.0 1
Glutamate NMDA receptor
CHEMBL1907608
IC50 4.99 4.99 10300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26117647 10.1016/j.bmc.2015.06.012 Glutamate NMDA receptor 4
- 10.1007/s00044-005-0130-2 Unchecked 2
- 10.1007/s00044-005-0130-2 Malme-3M 1
- 10.1007/s00044-005-0130-2 SR 1
- 10.1007/s00044-005-0130-2 A498 1
- 10.1007/s00044-005-0130-2 DNA 1
- 10.1007/s00044-005-0130-2 MCF7 1
- 10.1007/s00044-005-0130-2 SF-268 1
- 10.1007/s00044-005-0130-2 NCI-H460 1
- 10.1007/s00044-005-0130-2 Pneumocystis carinii 1

Data from ChEMBL 36 via Core Engine