Assay Detail
Binding
CHEMBL3088372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FMS in mouse BMDM cells
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL5570) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 7.76 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086175 | — | — | 1 | 8.74 |
| CHEMBL3086316 | — | — | 1 | 8.74 |
| CHEMBL3085978 | — | — | 1 | 8.59 |
| CHEMBL3086178 | — | — | 1 | 8.53 |
| CHEMBL3085830 | — | — | 1 | 8.29 |
| CHEMBL3085976 | — | — | 1 | 8.24 |
| CHEMBL3085831 | — | — | 1 | 8.22 |
| CHEMBL3085833 | — | — | 1 | 8.21 |
| CHEMBL3086320 | — | — | 1 | 8.20 |
| CHEMBL3086319 | — | — | 1 | 8.11 |
| CHEMBL3085834 | — | — | 1 | 8.11 |
| CHEMBL3085829 | — | — | 1 | 8.08 |
| CHEMBL3086177 | — | — | 1 | 8.03 |
| CHEMBL3086321 | — | — | 1 | 8.01 |
| CHEMBL3085973 | — | — | 1 | 7.89 |
| CHEMBL3086179 | — | — | 1 | 7.89 |
| CHEMBL3085984 | — | — | 1 | 7.89 |
| CHEMBL3085832 | — | — | 1 | 7.89 |
| CHEMBL3086317 | — | — | 1 | 7.89 |
| CHEMBL3085828 | — | — | 1 | 7.77 |
| CHEMBL3085975 | — | — | 1 | 7.77 |
| CHEMBL3086174 | — | — | 1 | 7.75 |
| CHEMBL3085974 | — | — | 1 | 7.75 |
| CHEMBL3085972 | — | — | 1 | 7.72 |
| CHEMBL3085983 | — | — | 1 | 7.70 |
| CHEMBL3086323 | — | — | 1 | 7.68 |
| CHEMBL3086318 | — | — | 1 | 7.64 |
| CHEMBL3086315 | — | — | 1 | 7.60 |
| CHEMBL3085981 | — | — | 1 | 7.60 |
| CHEMBL3085971 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086175 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3086316 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3085978 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3086178 | — | IC50 | = | 2.921 | nM | 8.53 |
| CHEMBL3085830 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3085976 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3085831 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3085833 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3086320 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3086319 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3085834 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3085829 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3086177 | — | IC50 | = | 9.423 | nM | 8.03 |
| CHEMBL3086321 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3086317 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3085973 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3085984 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3085832 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3086179 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3085828 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3085975 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3086174 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3085974 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3085972 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3085983 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3086323 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3086318 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3086315 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3085981 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3085971 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3086322 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3086171 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3086162 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3085969 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3086325 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3086173 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3085985 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3085982 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3085970 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3086166 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3086314 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3085977 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3086176 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3086163 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3086168 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3085986 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL3086160 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3085827 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3085980 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL3086170 | — | IC50 | > | 300.0 | nM | - |