Compound Detail
CHEMBL3085982
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Basic Information
| ChEMBL ID | CHEMBL3085982 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WQLYJHDWSZURLE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
399.5
MW (Da)
2.32
ALogP
5
HBA
3
HBD
141.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL5570 | IC50 | 7.27 | 7.27 | 54.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 2.4 | nM | 8.62 | Inhibition of FMS (unknown origin) | 24138939 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 54.0 | nM | 7.27 | Inhibition of FMS in mouse BMDM cells | 24138939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24138939 | 10.1016/j.bmcl.2013.09.061 | Macrophage colony-stimulating factor 1 receptor | 2 |
| 24138939 | 10.1016/j.bmcl.2013.09.061 | Liver microsome | 1 |
| 24138939 | 10.1016/j.bmcl.2013.09.061 | Unchecked | 1 |
| 24138939 | 10.1016/j.bmcl.2013.09.061 | Mast/stem cell growth factor receptor Kit | 1 |
Data from ChEMBL 36 via Core Engine