Assay Detail
Functional
CHEMBL3090715
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Trypanocidal activity against intracellular amastigote stage of Trypanosoma cruzi CL-B5 infected in mouse NCTC-929 cells assessed as reduction of parasite load after 7 days by resazurin dye-based fluorometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | NCTC-929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.73 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424146 | — | — | 1 | 4.91 |
| CHEMBL3085899 | — | — | 1 | 4.54 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
| CHEMBL3085903 | — | — | 1 | - |
| CHEMBL3085901 | — | — | 1 | - |
| CHEMBL3085895 | — | — | 1 | - |
| CHEMBL3085892 | — | — | 1 | - |
| CHEMBL3085886 | — | — | 1 | - |
| CHEMBL594928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424146 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL3085899 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 192100.0 | nM | - |
| CHEMBL3085903 | — | IC50 | - | — | - | |
| CHEMBL3085901 | — | IC50 | - | — | - | |
| CHEMBL3085895 | — | IC50 | - | — | - | |
| CHEMBL3085892 | — | IC50 | - | — | - | |
| CHEMBL3085886 | — | IC50 | = | 141150.0 | nM | - |
| CHEMBL594928 | — | IC50 | = | 223700.0 | nM | - |