Assay Detail
Functional
CHEMBL3136232
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Cytotoxicity against human THLE cells assessed as ATP depletion after 72 hrs by CellTitre-Glo assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THLE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical motifs that redox cycle and their associated toxicity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 5.25 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.28 |
| CHEMBL417799 | SANGUINARIUM | 2.0 | 1 | 6.03 |
| CHEMBL3134045 | — | — | 1 | 5.77 |
| CHEMBL1525075 | — | — | 1 | 5.70 |
| CHEMBL2094294 | — | — | 1 | 5.51 |
| CHEMBL1316847 | — | — | 1 | 5.51 |
| CHEMBL578512 | — | — | 1 | 5.50 |
| CHEMBL3134043 | — | — | 1 | 5.50 |
| CHEMBL3134044 | — | — | 1 | 5.17 |
| CHEMBL1517074 | — | — | 1 | 5.14 |
| CHEMBL1527391 | — | — | 1 | 5.13 |
| CHEMBL3134047 | — | — | 1 | 5.09 |
| CHEMBL1325945 | — | — | 1 | 4.89 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.75 |
| CHEMBL354201 | — | — | 1 | 4.68 |
| CHEMBL349147 | — | — | 1 | 4.43 |
| CHEMBL3134048 | — | — | 1 | 4.17 |
| CHEMBL68500 | ALLOXAZINE | — | 1 | - |
| CHEMBL1534 | RIBOFLAVIN | 4.0 | 1 | - |
| CHEMBL3134054 | — | — | 1 | - |
| CHEMBL3134046 | — | — | 1 | - |
| CHEMBL1234104 | — | — | 1 | - |
| CHEMBL3134049 | — | — | 1 | - |
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | - |
| CHEMBL5 | NALIDIXIC ACID | 4.0 | 1 | - |
| CHEMBL3134050 | — | — | 1 | - |
| CHEMBL74469 | PARAQUAT | — | 1 | - |
| CHEMBL3134051 | — | — | 1 | - |
| CHEMBL3134052 | — | — | 1 | - |
| CHEMBL2107135 | TESIMIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL417799 | SANGUINARIUM | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3134045 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1525075 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2094294 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1316847 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL578512 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3134043 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3134044 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1517074 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1527391 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3134047 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1325945 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL590 | MENADIONE | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL354201 | — | EC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL349147 | — | EC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL3134048 | — | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL68500 | ALLOXAZINE | EC50 | > | 300000.0 | nM | - |
| CHEMBL1534 | RIBOFLAVIN | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134054 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134046 | — | EC50 | = | 245000.0 | nM | - |
| CHEMBL1234104 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134049 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL9 | NORFLOXACIN | EC50 | > | 300000.0 | nM | - |
| CHEMBL5 | NALIDIXIC ACID | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134050 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL74469 | PARAQUAT | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134051 | — | EC50 | = | 117000.0 | nM | - |
| CHEMBL3134052 | — | EC50 | = | 108000.0 | nM | - |
| CHEMBL2107135 | TESIMIDE | EC50 | > | 300000.0 | nM | - |
| CHEMBL3134053 | — | EC50 | > | 300000.0 | nM | - |