Assay Detail
Binding
CHEMBL3137111
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Binding affinity to recombinant human PHD3-Fe2+ complex expressed in Escherichia coli using HIF19 peptide as substrate by fluorescence emission spectroscopy
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azole derivatives as novel non-iron-chelating inhibitors of prolyl hydroxylase 3 for HIF-1 activation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 10.40 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3133889 | — | — | 1 | 10.82 |
| CHEMBL20724 | — | — | 1 | 10.26 |
| CHEMBL3133888 | — | — | 1 | 10.11 |
| CHEMBL3133892 | — | — | 1 | - |
| CHEMBL3133891 | — | — | 1 | - |
| CHEMBL84963 | BENZOTRIAZOLE | — | 1 | - |
| CHEMBL306226 | BENZIMIDAZOLE | -1.0 | 1 | - |
| CHEMBL3133890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3133889 | — | Kd | = | 0.0152 | nM | 10.82 |
| CHEMBL20724 | — | Kd | = | 0.0544 | nM | 10.26 |
| CHEMBL3133888 | — | Kd | = | 0.0784 | nM | 10.11 |
| CHEMBL3133892 | — | Kd | = | 0.00734 | nM | - |
| CHEMBL3133891 | — | Kd | = | 0.00567 | nM | - |
| CHEMBL84963 | BENZOTRIAZOLE | Kd | - | — | - | |
| CHEMBL306226 | BENZIMIDAZOLE | Kd | - | — | - | |
| CHEMBL3133890 | — | Kd | = | 0.00347 | nM | - |