Assay Detail
Binding
CHEMBL3224088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at N-terminal His6-tagged L3MBTL1 (unknown origin) expressed in Escherichia coli BL21 Codon Plus RIL cells assessed as inhibition of L3MBTL1/biotinylated H4K20Me1 peptide interaction after 30 mins by AlphaScreen assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Plus RIL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lethal(3)malignant brain tumor-like protein 1 (CHEMBL1287622) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structureactivity relationships of methyl-lysine reader antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.85 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426369 | — | — | 1 | 5.41 |
| CHEMBL1235119 | — | — | 1 | 5.10 |
| CHEMBL3220197 | — | — | 1 | 5.07 |
| CHEMBL3220190 | — | — | 1 | 4.88 |
| CHEMBL3219947 | — | — | 1 | 4.83 |
| CHEMBL3219949 | — | — | 1 | 4.75 |
| CHEMBL3220204 | — | — | 1 | 4.69 |
| CHEMBL3219948 | — | — | 1 | 4.64 |
| CHEMBL2426371 | — | — | 1 | 4.63 |
| CHEMBL3220201 | — | — | 1 | 4.54 |
| CHEMBL3220189 | — | — | 1 | - |
| CHEMBL3220191 | — | — | 1 | - |
| CHEMBL3220192 | — | — | 1 | - |
| CHEMBL3220193 | — | — | 1 | - |
| CHEMBL3220194 | — | — | 1 | - |
| CHEMBL3220195 | — | — | 1 | - |
| CHEMBL3220196 | — | — | 1 | - |
| CHEMBL2426372 | — | — | 1 | - |
| CHEMBL3220198 | — | — | 1 | - |
| CHEMBL3220199 | — | — | 1 | - |
| CHEMBL3220200 | — | — | 1 | - |
| CHEMBL3220202 | — | — | 1 | - |
| CHEMBL3217781 | — | — | 1 | - |
| CHEMBL3220203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426369 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1235119 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3220197 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3220190 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3219947 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3219949 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3220204 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3219948 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL2426371 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL3220201 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL3220189 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220191 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220192 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220193 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220194 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220195 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220196 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2426372 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220198 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220199 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220200 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220202 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3217781 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220203 | — | IC50 | > | 30000.0 | nM | - |