Compound Detail
CHEMBL2426371
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Basic Information
| ChEMBL ID | CHEMBL2426371 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YMTXFWXRZYKGBA-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
363.3
MW (Da)
3.40
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | IC50 | 5.5 | 5.47 | 3200.0 | 2 |
| Lethal(3)malignant brain tumor-like protein 1 CHEMBL1287622 | IC50 | 4.69 | 4.66 | 20600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 3600.0 | nM | 5.44 | Antagonist activity at His-tagged L3MBTL3 (unknown origin) assessed as inhibitio... | - |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 20600.0 | nM | 4.69 | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 23600.0 | nM | 4.63 | Antagonist activity at N-terminal His6-tagged L3MBTL1 (unknown origin) expressed... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 4 | 2 |
| - | 10.1039/C1MD00195G | MBT domain-containing protein 1 | 2 |
| - | 10.1039/C1MD00195G | Scm-like with four MBT domains protein 1 | 2 |
| - | 10.1039/C1MD00195G | Chromobox protein homolog 7 | 2 |
| 24040942 | 10.1021/jm400919p | Lethal(3)malignant brain tumor-like protein 1 | 1 |
| 24040942 | 10.1021/jm400919p | Lethal(3)malignant brain tumor-like protein 3 | 1 |
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 3 | 1 |
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 1 | 1 |
Data from ChEMBL 36 via Core Engine