Assay Detail
Binding
CHEMBL3224090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at His-tagged L3MBTL3 (unknown origin) assessed as inhibition of L3MBTL3/biotinylated H4K20Me2 peptide interaction after 30 mins by AlphaScreen assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lethal(3)malignant brain tumor-like protein 3 (CHEMBL1287623) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structureactivity relationships of methyl-lysine reader antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.17 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220204 | — | — | 1 | 5.62 |
| CHEMBL2426369 | — | — | 1 | 5.50 |
| CHEMBL2426371 | — | — | 1 | 5.44 |
| CHEMBL3220202 | — | — | 1 | 5.43 |
| CHEMBL3219947 | — | — | 1 | 5.39 |
| CHEMBL1235119 | — | — | 1 | 5.32 |
| CHEMBL3219949 | — | — | 1 | 5.21 |
| CHEMBL3220190 | — | — | 1 | 5.19 |
| CHEMBL3220201 | — | — | 1 | 5.17 |
| CHEMBL3219948 | — | — | 1 | 5.17 |
| CHEMBL3220189 | — | — | 1 | 5.16 |
| CHEMBL3220197 | — | — | 1 | 5.06 |
| CHEMBL3217781 | — | — | 1 | 4.88 |
| CHEMBL3220203 | — | — | 1 | 4.80 |
| CHEMBL3220198 | — | — | 1 | 4.68 |
| CHEMBL3220195 | — | — | 1 | 4.62 |
| CHEMBL3220191 | — | — | 1 | - |
| CHEMBL3220192 | — | — | 1 | - |
| CHEMBL3220193 | — | — | 1 | - |
| CHEMBL3220194 | — | — | 1 | - |
| CHEMBL3220196 | — | — | 1 | - |
| CHEMBL2426372 | — | — | 1 | - |
| CHEMBL3220199 | — | — | 1 | - |
| CHEMBL3220200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220204 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2426369 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2426371 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3220202 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3219947 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1235119 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3219949 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3220190 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3220201 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3219948 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3220189 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3220197 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3217781 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3220203 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3220198 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3220195 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3220191 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220192 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220193 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220194 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220196 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2426372 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220199 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3220200 | — | IC50 | > | 30000.0 | nM | - |