Compound Detail
CHEMBL3219949
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Basic Information
| ChEMBL ID | CHEMBL3219949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DGSWWZXXNOBKHV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
258.4
MW (Da)
2.39
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.81
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | IC50 | 5.21 | 5.21 | 6200.0 | 1 |
| Lethal(3)malignant brain tumor-like protein 1 CHEMBL1287622 | IC50 | 4.75 | 4.75 | 17800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 6200.0 | nM | 5.21 | Antagonist activity at His-tagged L3MBTL3 (unknown origin) assessed as inhibitio... | - |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 17800.0 | nM | 4.75 | Antagonist activity at N-terminal His6-tagged L3MBTL1 (unknown origin) expressed... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C1MD00195G | MBT domain-containing protein 1 | 2 |
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 4 | 2 |
| - | 10.1039/C1MD00195G | Scm-like with four MBT domains protein 1 | 2 |
| - | 10.1039/C1MD00195G | Chromobox protein homolog 7 | 2 |
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 3 | 1 |
| - | 10.1039/C1MD00195G | Lethal(3)malignant brain tumor-like protein 1 | 1 |
Data from ChEMBL 36 via Core Engine