Assay Detail
ADMET
CHEMBL3240531
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Inhibition of CYP3A4 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.64 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237442 | — | — | 1 | 6.26 |
| CHEMBL3237704 | — | — | 1 | 5.02 |
| CHEMBL3237443 | — | — | 1 | - |
| CHEMBL3237444 | — | — | 1 | - |
| CHEMBL3237445 | — | — | 1 | - |
| CHEMBL3237448 | — | — | 1 | - |
| CHEMBL3237449 | — | — | 1 | - |
| CHEMBL3237703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237442 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3237704 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3237443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3237444 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3237445 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3237448 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3237449 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3237703 | — | IC50 | > | 10000.0 | nM | - |